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2-羟基肉桂醛

2-羟基肉桂醛用途

2-羟基肉桂醛是从肉桂树皮中分离得到的一种苯丙烷类化合物。2-羟基肉桂醛抑制Wnt/β-catenin、STAT3信号传导。2-羟基肉桂醛诱导细胞凋亡2-羟基肉桂甲醛具有抗肿瘤和抗炎活性[1][2][3]。

2-羟基肉桂醛名称

[ CAS 号 ]:
3541-42-2

[ 中文名 ]:
2-羟基肉桂醛

[ 英文名 ]:
(2E)-3-(2-hydroxyphenyl)prop-2-enal

[英文别名 ]:

(2E)-3-(2-Hydroxyphenyl)acrylaldehyde
Hydroxycinnamaldehyde
o-hydroxycinnamaldehyde
(2E)-3-(2-hydroxyphenyl)prop-2-enal
2'-hydroxycinnamaldehyde
3-(2-Hydroxyphenyl)acrylaldehyde
2-Propenal, 3-(2-hydroxyphenyl)-, (2E)-
2-Hydroxy-zimtaldehyd
2-hydroxycinnamicaldehyde
o-hydroxy-cinnamaldehyd

2-羟基肉桂醛生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号

信号通路 >> JAK/STAT信号通路 >> STAT

研究领域 >> 炎症/免疫

[参考文献]

[1]. Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84.

[2]. Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55.

[3]. Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884.

2-羟基肉桂醛物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
311.3±17.0 °C at 760 mmHg

[ 熔点 ]:
126ºC

[ 分子式 ]:
C₉H₈O₂

[ 分子量 ]:
148.16

[ 闪点 ]:
131.8±13.5 °C

[ 精确质量 ]:
148.052429

[ PSA ]:
37.30000

[ LogP ]:
2.14

[ 外观性状 ]:
浅黄色-黄色晶体-粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
室温，干燥

2-羟基肉桂醛MSDS

详细MSDS(安全技术说明书)

2-羟基肉桂醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD6565000

CHEMICAL NAME :: Cinnamaldehyde, o-hydroxy-

CAS REGISTRY NUMBER :: 3541-42-2

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H8-O2

MOLECULAR WEIGHT :: 148.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 19,191,1985

2-羟基肉桂醛安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
2912499000

2-羟基肉桂醛海关

[ 海关编码 ]: 2912499000

[ 中文概述 ]:
2912499000. 其他醛醚、醛酚及含其他含氧基的醛. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%