橄榄苦苷

橄榄苦苷用途

Oleuropein 在橄榄叶和油中发现的,可通过直接抑制 PPARγ 转录活性来发挥抗氧化,抗炎和抗动脉粥样硬化作用。Oleuropein 通过 p53 依赖性途径以及 Bax 和 Bcl2 基因的调控来诱导乳腺癌细胞凋亡。Oleuropein 还抑制芳香化酶 (aromatase)。

橄榄苦苷名称

[ CAS 号 ]:
32619-42-4

[ 中文名 ]:
橄榄苦甙

[ 英文名 ]:
Oleuropein

[中文别名 ]:

[英文别名 ]:

Olive Leaf Extract
MFCD00017493
Oleuropein
oleuropein glucoside
EINECS 251-129-6

橄榄苦苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 炎症/免疫

信号通路 >> 其他 >> 芳香

[ 靶点 ]

PPARγ

Apoptosis

Aromatase

[体外研究]

芳香化酶是一种细胞色素P450酶,是乳腺癌治疗的重要药物靶点[2]。

[参考文献]

[1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376.

[2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.

橄榄苦苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
772.9±60.0 °C at 760 mmHg

[ 熔点 ]:
89-90ºC

[ 分子式 ]:
C₂₅H₃₂O₁₃

[ 分子量 ]:
540.514

[ 闪点 ]:
257.0±26.4 °C

[ 精确质量 ]:
540.184265

[ PSA ]:
201.67000

[ LogP ]:
-0.91

[ 外观性状 ]:
棕色粉末

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
room temp

橄榄苦苷MSDS

详细MSDS(安全技术说明书)

橄榄苦苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2938909090

橄榄苦苷上下游产品

橄榄苦苷上游产品

橄榄苦苷下游产品

橄榄苦苷海关

[ 海关编码 ]: 2938909090

橄榄苦苷文献

Rapid screening of oleuropein from olive leaves using matrix solid-phase dispersion and high-performance liquid chromatography.

J. AOAC Int. 97(4) , 1109-13, (2014)

Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with convention...

A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS.

J. Pharm. Biomed. Anal. 72 , 121-6, (2013)

Olive leaves, an easily available natural low-cost material, constitute a source of extracts with significant antitumor activity that inhibits cell proliferation in several breast-cancer-cell models. ...

Antiproliferative effect of oleuropein in prostate cell lines.

Int. J. Oncol. 41(1) , 31-8, (2012)

Currently, there is increasing interest in the in vivo protective effects of natural antioxidants found in dietary plants against oxidative damage caused by free radical species. Oxidative stress has ...

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