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溴甲贝那替秦

溴甲贝那替秦用途

Methylbenactyzium Bromide 是一种毒蕈碱性乙酰胆碱受体 (mAChR) 抑制剂。

溴甲贝那替秦名称

[ CAS 号 ]:
3166-62-9

[ 中文名 ]:
溴甲乙胺痉平

[ 英文名 ]:
Methylbenactyzium Bromide

[中文别名 ]:

[英文别名 ]:

Semulgin
Sanrine
Igsain
Benactyzin-methobromid
Noinarin
Finalin
Alsain
EINECS 221-628-3
Gastrimade
Paragone

溴甲贝那替秦生物活性

[ 描述 ]:

Methylbenactyzium Bromide 是一种毒蕈碱性乙酰胆碱受体 (mAChR) 抑制剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 炎症/免疫

[ 靶点 ]

mAChR[1]

[体外研究]

Methylbenactyzium Bromide是一种毒蕈碱乙酰胆碱受体(mAChR)抑制剂[1]。甲基苯丙嗪已被用作解痉剂用于治疗胃肠溃疡[2]。

[参考文献]

[1]. Bhattacharjee AK, et al. Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg Med Chem. 2013 May 1;21(9):2651-62.

[2]. Nishikawa M, et al. Analysis of methylbenactyzium bromide in human urine by thin-layer chromatography and pyrolysis gas chromatography. Forensic Sci Int. 1991 Mar;49(2):197-203.

[相关活性小分子]

溴甲贝那替秦物理化学性质

[ 分子式 ]:
C₂₁H₂₈BrNO₃

[ 分子量 ]:
422.356

[ 精确质量 ]:
421.125244

[ PSA ]:
46.53000

溴甲贝那替秦毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP7524000

CHEMICAL NAME :: Ammonium, diethyl(2-hydroxyethyl)methyl-, bromide, benzilate (ester)

CAS REGISTRY NUMBER :: 3166-62-9

LAST UPDATED :: 199007

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H28-N-O3.Br

MOLECULAR WEIGHT :: 422.41

WISWESSER LINE NOTATION :: 2K2&1&2OVXQR&R &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,358,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,358,1982

溴甲贝那替秦安全信息

[ 海关编码 ]:
2923900090

溴甲贝那替秦上下游产品

溴甲贝那替秦上游产品

溴甲贝那替秦下游产品

溴甲贝那替秦海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%