胡黄连苷I

胡黄连苷I用途

Picroside I 是 Picrorhiza kurroa 的一种主要成分。Picrorhiza kurroa 是一种高价值的药用植物,富含肝脏保护代谢物 Picroside I 和 Picroside-II。Picroside I 是一种哮喘治疗药物。Picroside I 可显着减轻炎症。Picroside I 还下调 pSTAT6 和 GATA3 表达。Picroside I 剂量依赖性地增加血清 IFN-γ 水平。

胡黄连苷I名称

[ CAS 号 ]:
27409-30-9

[ 中文名 ]:
胡黄连苷I

[ 英文名 ]:
Picroside I

[中文别名 ]:

胡黄连苷 I

[英文别名 ]:

picroside-1
PicrosideI
6'-O-trans-cinnamoylcatalpol
picrosides I
Picroside I

胡黄连苷I生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

信号通路 >> JAK/STAT信号通路 >> STAT

研究领域 >> 炎症/免疫

[ 靶点 ]

STAT6

[参考文献]

[1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56.

[2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.

胡黄连苷I物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
739.1±60.0 °C at 760 mmHg

[ 熔点 ]:
130 °C

[ 分子式 ]:
C₂₄H₂₈O₁₁

[ 分子量 ]:
492.473

[ 闪点 ]:
253.2±26.4 °C

[ 精确质量 ]:
492.163147

[ PSA ]:
167.67000

[ LogP ]:
-1.81

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: soluble1mg/mL, clear, colorless

胡黄连苷I安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
29389090

胡黄连苷I文献

Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.

Eur. J. Pharmacol. 406(2) , 203-8, (2000)

Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyr...

Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.

Life Sci. 71(15) , 1821-35, (2002)

Picrosides I and II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-ind...

De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments.

BMC Genomics 13 , 126, (2012)

Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature...

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