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苯磺酸贝托司汀

苯磺酸贝托司汀用途

Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。

苯磺酸贝托司汀名称

[ CAS 号 ]:
190786-44-8

[ 中文名 ]:
苯磺酸贝托司汀

[ 英文名 ]:
Bepotastine Besilate

[中文别名 ]:

[英文别名 ]:

Bepotastine benzenesulfonate salt
UNII:6W18MO1QR3
Bepotastine Besilate
Talion
Bepotastine besylate
UNII-6W18MO1QR3
TAU-284
Bepotastine benzenesulfonate
Betotastine besilate
Bepotastine (Beslilate)

苯磺酸贝托司汀生物活性

[ 描述 ]:

Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Cho KH, Choi HG.Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs.Drug Dev Ind Pharm. 2012 Sep 10.

[2]. Meier EJ, Torkildsen GL, Gow JA, McNamara TR, Gomes PJ, Williams JI; for the Bepotastine Besilate Ophthalmic Solutions Study Group.Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular itching associated with allergic con

[3]. Kawakami T, Kimura S, Haga T, Doi R, Kyoya M, Nakagawa K, Soma Y.Health-related quality of life assessed by the effect of bepotastine besilate in patients with pruritus: importance of emotions score in atopic dermatitis.J Dermatol. 2012 Jun;39(6):527-30.

[4]. Williams JI, Kennedy KS, Gow JA, Torkildsen GL, Abelson MB, Gomes PJ, McNamara TR; Bepotastine Besilate Ophthalmic Solutions Study Group.Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allergic c

[5]. Kida, Tetsuo; Fujii, Atsuko; Sakai, Osamu; Iemura, Masahito; Atsumi, Ikuyo; Wada, Tomoyuki; Sakaki, Hideyuki. Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in i

[相关活性小分子]

苯磺酸贝托司汀物理化学性质

[ 沸点 ]:
546.8ºC at 760 mmHg

[ 熔点 ]:
161-163°

[ 分子式 ]:
C₂₇H₃₁ClN₂O₆S

[ 分子量 ]:
547.063

[ 闪点 ]:
284.5ºC

[ 精确质量 ]:
546.159119

[ PSA ]:
125.41000

[ LogP ]:
6.12220

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
8.63E-13mmHg at 25°C

[ 储存条件 ]:
<0°C;存放于惰性气体之中;避免湿气 (吸湿),加热

[ 水溶解性 ]:
水溶性：微溶；可溶于：甲醇；微溶：乙醇；不溶：二乙醚

苯磺酸贝托司汀安全信息

[ 危害码 (欧洲) ]:
Xi

苯磺酸贝托司汀

苯磺酸贝托司汀用途

苯磺酸贝托司汀名称

苯磺酸贝托司汀生物活性

苯磺酸贝托司汀物理化学性质

苯磺酸贝托司汀安全信息

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