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匹利诺生

匹利诺生用途

IB-MECA是一种腺苷A 3受体激动剂, EC50值为0.11 μM。

匹利诺生名称

[ CAS 号 ]:
152918-18-8

[ 中文名 ]:
1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide

[ 英文名 ]:
IB-MECA

[中文别名 ]:

匹利诺生

[英文别名 ]:

UNII-30679UMI0N
Piclidenoson
IBMECA
CF 101
3-IB-Meca
IB-MECA
CF101

匹利诺生生物活性

[ 描述 ]:

Piclidenoson (IB-MECA) 是一种腺苷A 3受体激动剂, EC50值为0.11 μM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 癌症

[参考文献]

[1]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215.

[2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039.

[3]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46.

[相关活性小分子]

匹利诺生物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 分子式 ]:
C₁₈H₁₉IN₆O₄

[ 分子量 ]:
510.286

[ 精确质量 ]:
510.051239

[ PSA ]:
134.42000

[ LogP ]:
2.08

[ 折射率 ]:
1.808

[ 储存条件 ]:
2-8°C，避光干燥密封

匹利诺生安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

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匹利诺生海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

匹利诺生文献

Equilibrium and kinetic selectivity profiling on the human adenosine receptors.

Biochem. Pharmacol. 105 , 34-41, (2016)

Classical evaluation of target selectivity is usually undertaken by measuring the binding affinity of lead compounds against a number of potential targets under equilibrium conditions, without conside...

Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.

J. Thorac. Cardiovasc. Surg. 140(2) , 440-6, (2010)

Adenosine and the activation of specific adenosine receptors are implicated in the attenuation of inflammation and organ ischemia-reperfusion injury. We hypothesized that activation of A(1), A(2A), or...

Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

Am. J. Physiol. Gastrointest. Liver Physiol. 297(6) , G1147-62, (2009)

We tested the novel hypothesis that endogenous adenosine (eADO) activates low-affinity A3 receptors in a model of neurogenic diarrhea in the guinea pig colon. Dimaprit activation of H2 receptors was u...

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