5-(N,N-六亚甲基)阿米洛利

5-(N,N-六亚甲基)阿米洛利用途

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride),是 amiloride 的衍生物,也是一种有效的 Na+/H+ 交换抑制剂,降低白血病细胞的细胞内 pH (pHi) 并诱导其凋亡。5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) 也是一种 HIV-1 Vpu 病毒离子通道抑制剂,抑制培养在 L929 细胞中的小鼠肝炎病毒 (MHV) 复制和人冠状病毒 229E (HCoV229E) 复制,EC50 值分别为 3.91 μM 和 1.34 μM。

5-(N,N-六亚甲基)阿米洛利名称

[ CAS 号 ]:
1428-95-1

[ 中文名 ]:
阿米洛利

[ 英文名 ]:
5-(N,N-Hexamethylene)-amiloride

[英文别名 ]:

HMA
HMA-5
Hexamethyleneamiloride

5-(N,N-六亚甲基)阿米洛利生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 癌症

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[ 靶点 ]

Na+/H+ exchanger[1] EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]

[参考文献]

[1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34.

[2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3.

5-(N,N-六亚甲基)阿米洛利物理化学性质

[ 密度 ]:
1.63g/cm3

[ 沸点 ]:
638.2ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₈ClN₇O

[ 分子量 ]:
311.77100

[ 闪点 ]:
339.8ºC

[ 精确质量 ]:
311.12600

[ PSA ]:
136.51000

[ LogP ]:
2.55300

[ 蒸汽压 ]:
3.47E-16mmHg at 25°C

[ 折射率 ]:
1.742

[ 储存条件 ]:
2-8°C

5-(N,N-六亚甲基)阿米洛利安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
23/24/25

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934999090

5-(N,N-六亚甲基)阿米洛利海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-(N,N-六亚甲基)阿米洛利文献

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Colloids Surf. B Biointerfaces 133 , 148-55, (2015)

Electrospun nanofibers with antibacterial activity are greatly promising for medical treatment and water purification. Herein we report antibacterial nanofibers electrospun from a series of poly(dimet...

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