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氯硝柳胺乙醇胺盐

氯硝柳胺乙醇胺盐用途

氯硝柳胺-乙醇胺是一种驱虫药,可以破坏寄生虫和动物模型的线粒体代谢。氯硝柳胺-乙醇胺通过可逆性抑制雷帕霉素复合物1(mTORC1)信号传导抑制STAT3(IC50=0.25μM)并刺激自噬。

氯硝柳胺乙醇胺盐名称

[ CAS 号 ]:
1420-04-8

[ 中文名 ]:
杀螺胺乙醇胺盐

[ 英文名 ]:
Niclosamide olamine

[中文别名 ]:

[英文别名 ]:

Luomiecide
Hl 2448
MFCD01941566
EINECS 215-811-7
Mollutox
2',5-dichloro-4'-nitrosalicylanilide
clonitralid
Niclosamide ethanolamine salt
BAYER73
BAY-73

氯硝柳胺乙醇胺盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

信号通路 >> JAK/STAT信号通路 >> STAT

信号通路 >> 自噬 >> 自噬

氯硝柳胺乙醇胺盐物理化学性质

[ 沸点 ]:
155-156 °C

[ 熔点 ]:
91-93 °C(lit.)

[ 分子式 ]:
C₁₅H₁₅Cl₂N₃O₅

[ 分子量 ]:
386.230

[ 闪点 ]:
149 °F

[ 精确质量 ]:
385.059601

[ PSA ]:
141.40000

[ LogP ]:
4.09340

[ 外观性状 ]:
黄色固体

[ 储存条件 ]:
2-8°C，避光，保存于惰性气体中

[ 稳定性 ]:
Stable. Hydrolyzes in concentrated acidic or basic solutions.

[ 水溶解性 ]:
soluble

氯硝柳胺乙醇胺盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8575000

CAS REGISTRY NUMBER :: 1420-04-8

LAST UPDATED :: 199607

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H8-Cl2-N2-O4.C2-H7-N-O

MOLECULAR WEIGHT :: 388.23

WISWESSER LINE NOTATION :: WNR CG DMVR BQ EG &Z2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,103,1976/1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,126,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 336600 ug/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 53,1,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

氯硝柳胺乙醇胺盐安全信息

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 1325 4.1/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1