邻苯二甲酸二戊酯

邻苯二甲酸二戊酯用途

Dipentyl phthalate 是一种内分泌干扰性邻苯二甲酸酯增塑剂。Dipentyl phthalate 可增加 AMPK 磷酸化并降低 AKT1 磷酸化和 SIRT1 水平。Dipentyl phthalate 可降低促肾上腺皮质激素水平。Dipentyl phthalate 是一种睾丸毒物。

邻苯二甲酸二戊酯名称

[ CAS 号 ]:
131-18-0

[ 中文名 ]:
邻苯二甲酸二戊酯

[ 英文名 ]:
Di-n-Amyl phthalate

[中文别名 ]:

[英文别名 ]:

phthalic acid dipentyl ester
MFCD01861607
1,2-Benzenedicarboxylic acid, dipentyl ester
EINECS 205-017-9
Di-n-pentyl-phthalate
dipentyl benzene-1,2-dicarboxylate
Phthalic acid diamyl ester
Phthalic acid, pentyl 2-pentyl ester
UNII-5DC92K224X
DIAMYLPHTHALATE

邻苯二甲酸二戊酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> AMPK

信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT

信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK

研究领域 >> 代谢疾病

[参考文献]

[1]. Haiqiong Chen,et al. Exposure to dipentyl phthalate in utero disrupts the adrenalcortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPKphosphorylation. Environ Toxicol. 2023 May;38(5):997-1010.

[2]. Bethany R Hannas,et al. Dipentyl phthalate dosing during sexual differentiation disruptsfetal testis function and postnatal development of the male Sprague-Dawley ratwith greater relative potency than other phthalates. Toxicol Sci. 2011Mar;120(1):184-93.

邻苯二甲酸二戊酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
357.0±10.0 °C at 760 mmHg

[ 熔点 ]:
-55ºC

[ 分子式 ]:
C₁₈H₂₆O₄

[ 分子量 ]:
306.40

[ 闪点 ]:
188.8±8.5 °C

[ 精确质量 ]:
306.183105

[ PSA ]:
52.60000

[ LogP ]:
5.89

[ 外观性状 ]:
液体;Colorless to Almost colorless clear liquid

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.496

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：不溶；水溶解度：0.8 mg/l 25 °C

邻苯二甲酸二戊酯MSDS

邻苯二甲酸二戊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI1930000

CHEMICAL NAME :: Phthalic acid, dipentyl ester

CAS REGISTRY NUMBER :: 131-18-0

BEILSTEIN REFERENCE NO. :: 1987323

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H26-O4

MOLECULAR WEIGHT :: 306.44

WISWESSER LINE NOTATION :: 5OVR BVO5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6600 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,120,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2206 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,265,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,528,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 316 gm/kg

SEX/DURATION :: male 15 week(s) pre-mating female 15 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,508,1989 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989

邻苯二甲酸二戊酯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360-H400

[ 警示性声明 ]:
P201-P273-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T: Toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R60

[ 安全声明 (欧洲) ]:
S45;S53;S61

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
TI1930000

[ 包装等级 ]:
III

[ 海关编码 ]:
2917349000

邻苯二甲酸二戊酯合成路线

邻苯二甲酸二戊酯上下游产品

邻苯二甲酸二戊酯上游产品

邻苯二甲酸二戊酯下游产品

邻苯二甲酸二戊酯海关

[ 海关编码 ]: 2917349000

[ 中文概述 ]:
2917349000 其他邻苯二甲酸酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

邻苯二甲酸二戊酯文献

Analysis of phthalates in milk and milk products by liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry.

J. Chromatogr. A. 1362 , 110-8, (2014)

A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, ef...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

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