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GR79236

GR79236用途

GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。

GR79236名称

[ CAS 号 ]:
124555-18-6

[ 中文名 ]:
GR79236

[ 英文名 ]:
GR 79236

[英文别名 ]:

HMS3268O08
N-[(1S (trans)-2-Hydroxycyclopentyl]adenosine
GR79236

GR79236生物活性

[ 描述 ]:

GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Sneyd JR, et al. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. Br J Anaesth. 2007 May;98(5):672-676.

[2]. Arulmani U, et al. Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs. Cephalalgia. 2005 Nov;25(11):1082-90.

[相关活性小分子]

GR79236物理化学性质

[ 密度 ]:
1.89g/cm3

[ 沸点 ]:
728.3ºC at 760mmHg

[ 分子式 ]:
C₁₅H₂₁N₅O₅

[ 分子量 ]:
351.35800

[ 闪点 ]:
394.3ºC

[ 精确质量 ]:
351.15400

[ PSA ]:
145.78000

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.846

[ 储存条件 ]:
2-8℃

GR79236安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

GR79236文献

Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction.

Br. J. Anaesth. 98(5) , 672-6, (2007)

Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.Seventy-nine patients ...

Does a selective adenosine A(1) receptor agonist protect against exercise induced ischaemia in patients with coronary artery disease?

Heart 87(2) , 115-20, (2002)

The "warm up" effect in angina may represent ischaemic preconditioning, which is mediated by adenosine A(1) receptors in most models.To investigate the effect of a selective A(1) agonist, GR79236 (Gla...

Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236.

Clin. Sci. 86(5) , 593-8, (1994)

1. We assessed the effect of a novel oral antilipolytic agent, N-[(1S, trans)-2-hydroxycyclopentyl]adenosine (GR 79236), in experimental diabetic ketoacidosis. Ketotic rats were gavaged with GR 79236 ...

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