PKA抑制剂片段(6-22)酰胺

PKA抑制剂片段(6-22)酰胺用途

PKA Inhibitor Fragment (6-22) amide 是 cAMP 依赖性蛋白激酶 A (PKA) 的抑制剂,Ki 值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide 可显着逆转小鼠低水平的吗啡镇痛感受性。

PKA抑制剂片段(6-22)酰胺名称

[ CAS 号 ]:
121932-06-7

[ 中文名 ]:
蛋白酶A抑制剂6-22酰胺

[ 英文名 ]:
PKA Inhibitor Fragment (6-22) amide

[中文别名 ]:

蛋白酶A抑制剂6-22 Amide

[英文别名 ]:

Protein Kinase A Inhibitor Fragment 6-22 amide
PKA inhibitor fragment (6-22) amide
MFCD00133792

PKA抑制剂片段(6-22)酰胺生物活性

[ 描述 ]:

PKA Inhibitor Fragment (6-22) amide 是 cAMP 依赖性蛋白激酶 A (PKA) 的抑制剂,Ki 值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide 可显着逆转小鼠低水平的吗啡镇痛感受性。

[ 相关类别 ]:

信号通路 >> 蛋白酪氨酸激酶 >> PKA

信号通路 >> 干细胞及 Wnt 通路 >> PKA

研究领域 >> 神经疾病

[ 靶点 ]

PKA:2.8 nM (Ki)

[参考文献]

[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439

[2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57.

PKA抑制剂片段(6-22)酰胺物理化学性质

[ 分子式 ]:
C₈₀H₁₃₀N₂₈O₂₄

[ 分子量 ]:
1868.06000

[ 精确质量 ]:
1866.98000

[ PSA ]:
881.72000

[ 外观性状 ]:
固体

[ 储存条件 ]:
−20°C

PKA抑制剂片段(6-22)酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

PKA抑制剂片段(6-22)酰胺文献

Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

J. Biol. Chem. 264 , 14579, (1989)

The minimal structure in the heat-stable inhibitor protein of cAMP-dependent protein kinase required for a low nanomolar potency of inhibition is the peptide Thr6-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-T...

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