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莫诺苯宗

莫诺苯宗用途

Monobenzone 是一种有效的皮肤脱色剂。Monobenzone 可引起色素脱失和活跃的人白癜风,有用于白癜风研究潜力。

莫诺苯宗名称

[ CAS 号 ]:
103-16-2

[ 中文名 ]:
莫诺苯宗

[ 英文名 ]:
4-Benzyloxyphenol

[中文别名 ]:

[英文别名 ]:

4-Benzyloxyphenol
4-(Benzyloxy)phenol
agerite
Phenol, p- (benzyloxy)-
Hydroquinone Monobenzyl Ether
EINECS 203-083-3
4-benzyloxy phenol
Phenol, 4-(phenylmethoxy)-
Phenol, 4- (phenylmethoxy)-
4-(Benzyloxy)benzolol

莫诺苯宗生物活性

[ 描述 ]:

Monobenzone 是一种有效的皮肤脱色剂。Monobenzone 可引起色素脱失和活跃的人白癜风,有用于白癜风研究潜力。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184.

莫诺苯宗物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
359.1±17.0 °C at 760 mmHg

[ 熔点 ]:
119-120 °C(lit.)

[ 分子式 ]:
C₁₃H₁₂O₂

[ 分子量 ]:
200.233

[ 闪点 ]:
213.4±5.9 °C

[ 精确质量 ]:
200.083725

[ PSA ]:
29.46000

[ LogP ]:
2.96

[ 外观性状 ]:
琥珀色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
slightly soluble

莫诺苯宗MSDS

莫诺苯宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7700000

CHEMICAL NAME :: Phenol, p-(benzyloxy)-

CAS REGISTRY NUMBER :: 103-16-2

BEILSTEIN REFERENCE NO. :: 1958305

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H12-O2

MOLECULAR WEIGHT :: 200.25

WISWESSER LINE NOTATION :: QR DO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,983,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 163 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4903 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 367 (estimated) No. of Female Employees: 16 (estimated)

莫诺苯宗安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36;R43

[ 安全声明 (欧洲) ]:
S24/25-S26-S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
SJ7700000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29095090

莫诺苯宗合成路线

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莫诺苯宗海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

莫诺苯宗文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.

Arch. Biochem. Biophys. 563 , 71-8, (2014)

Monobenzyl ether of hydroquinone (MBEH) is cytotoxic towards melanocytes. Its treatment efficacy is limited by an inability to eradicate stem cells. By contrast, 8-hydroxy-N,N-dipropyl-2-aminotetralin...

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