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扎达维林

扎达维林用途

Zardaverine是新型的PDE3和4抑制剂，IC50分别为0.5 uM和0.8 uM。

扎达维林名称

[ CAS 号 ]:
101975-10-4

[ 中文名 ]:
扎达维林

[ 英文名 ]:
Zardaverine

[中文别名 ]:

[英文别名 ]:

Zardaverine
zardaverinum
zardaverina

扎达维林生物活性

[ 描述 ]:

Zardaverine是新型的PDE3和4抑制剂,IC50分别为0.5 uM和0.8 uM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 炎症/免疫

[参考文献]

[1]. R.T. Schermuly, H. Leuchte, H.A. Ghofrani, et al. Zardaverine and aerosolised iloprost in a model of acute respiratoryfailure. ERJ, 2003 ,22 (2): 342-347.

[2]. D. Ukena, K. Rentz, C. Reiber, et al. Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Respiratory Medicine.1995, 89 ( 6) : 441-444.

[3]. Schade FU, Schudt C. The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages. European Journal of Pharmacology.1993, 230(1):9-14.

[相关活性小分子]

扎达维林物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₁₂H₁₀F₂N₂O₃

[ 分子量 ]:
268.216

[ 精确质量 ]:
268.065948

[ PSA ]:
64.21000

[ LogP ]:
0.90

[ 折射率 ]:
1.555

[ 储存条件 ]:
2-8℃

扎达维林MSDS

扎达维林安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

扎达维林合成路线

扎达维林上下游产品

扎达维林上游产品

扎达维林下游产品

扎达维林文献

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

ACS Chem. Biol. 9(11) , 2496-501, (2014)

Caffeine, the most consumed psychoactive substance worldwide, may have beneficial effects on Parkinson's disease (PD) therapy. The mechanism by which caffeine contributes to its antiparkinsonian effec...

Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.

J. Neuroimmunol. 284 , 18-29, (2015)

Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whethe...

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.

J. Biomol. Screen. 11(5) , 457-68, (2006)

The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds repre...

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