Canadian journal of chemistry

2, 2-Bis (ethylthio) ethanenitrile: preparation and use as a one or two carbon nucleophile

GS Bates, S Ramaswamy

文献索引：Bates, Gordon S.; Ramaswamy, S. Canadian Journal of Chemistry, 1983 , vol. 61, p. 2006 - 2009

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被引用次数: 4

摘要

2, 2-Bis (ethylthio) ethanenitrile 1 was prepared in high yield from 2, 2-bis (ethylthio) ethanal 2. Alkylation of the potassium salt of 1 with various alkylating agents and conjugate addition to cyclic α, β-unsaturated ketones provided high yields of the alkylation products of 1. The potential one and two carbon chain extension capability of this new reagent has been demonstrated.