Organic letters

A general and convenient catalytic synthesis of nitriles from amides and silanes

S Zhou, K Junge, D Addis, S Das, M Beller

文献索引：Zhou, Shaolin; Junge, Kathrin; Addis, Daniele; Das, Shoubhik; Beller, Matthias Organic Letters, 2009 , vol. 11, # 11 p. 2461 - 2464

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被引用次数: 80

摘要

A new and convenient protocol for the catalytic dehydration of aromatic and aliphatic amides using silanes in the presence of catalytic amounts of fluoride is presented. The synthesis of aliphatic and aromatic nitriles proceeds with high selectivity under mild conditions. Notably, a wide substrate range is converted in good to excellent yields.