Synlett

Highly convenient, one-pot synthesis of nitriles from aldehydes using the NH2OH· HCl/NaI/MeCN system

R Ballini, D Fiorini, A Palmieri

文献索引：Ballini, Roberto; Fiorini, Dennis; Palmieri, Alessandro Synlett, 2003 , # 12 p. 1841 - 1843

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被引用次数: 8

摘要

Abstract Direct transformation of both aliphatic and aromatic aldehydes to the corresponding nitriles, can be easily performed by the reaction of an aldehyde with a slight excess of hydroxylamine hydrochloride, in refluxing acetonitrile and in the presence of 0.5 equivalents of sodium iodide as catalyst.