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Tetrahedron

Direct transformation of N, N-disubstituted amides and isopropyl esters to nitriles

Y Suzuki, T Yoshino, K Moriyama, H Togo

文献索引:Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814

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被引用次数: 26

摘要

Abstract Various N, N-dimethyl amides, N-methoxy-N-methyl amides, and isopropyl esters were smoothly transformed into the corresponding nitriles in good to moderate yields by the treatment with diisobutylaluminium hydride, followed by treatment with molecular iodine in aq ammonia. The present reactions are novel one-pot and practical methods for the transformation of N, N-disubstituted amides and isopropyl esters into nitriles, through the ...

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