(|S|)-(-)-2-羧基环丁胺
(|S|)-(-)-2-羧基环丁胺结构式
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常用名 | (|S|)-(-)-2-羧基环丁胺 | 英文名 | L-Azetidine-2-carboxylic acid |
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| CAS号 | 2133-34-8 | 分子量 | 101.104 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 242.0±33.0 °C at 760 mmHg | |
| 分子式 | C4H7NO2 | 熔点 | 206-207 ºC | |
| MSDS | 美版 | 闪点 | 100.1±25.4 °C |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Hsp70 clears misfolded kinases that partitioned into distinct quality-control compartments.
Mol. Biol. Cell 26 , 1583-600, (2015) Hsp70 aids in protein folding and directs misfolded proteins to the cellular degradation machinery. We describe discrete roles of Hsp70,SSA1 as an important quality-control machinery that switches functions to ameliorate the cellular environment. SSA1 facilit... |
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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been... |
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Azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors: Synthesis, biological evaluation, and structure–activity relationship
Eur. J. Med. Chem. 45 , 2453-66, (2010) In this study azetidine derivatives representing conformationally constrained GABA or β-alanine analogs were evaluated for their potency as GABA-uptake inhibitors. The study comprised derivatives substituted in 2- as well as in 3-position with either an aceti... |
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Fine structure of extracellular matrix and basal laminae in two types of abnormal collagen production: L-proline analog-treated otocyst cultures and disproportionate micromelia (Dmm/Dmm) mutants.
Hear. Res. 107 , 125, (1997) L-Azetidine-2-carboxylic acid (LACA), a naturally occurring vegetable imino acid, can be incorporated into mammalian proteins in place of proline, thereby eliciting an inhibitory effect on collagen secretion. Exposure of explants of the embryonic mouse inner ... |
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Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.
Mol. Biol. Cell 21 , 2102-16, (2010) Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr... |
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Ascorbate affects proliferation of guinea-pig vascular smooth muscle cells by direct and extracellular matrix-mediated effects.
J. Mol. Cell. Cardiol. 29 , 3293, (1997) Proliferation of smooth muscle cells and deposition of extracellular matrix proteins are important events in the formation of atherosclerotic plaques. We have investigated the direct and matrix-mediated effects of ascorbate on the proliferation rate of vascul... |
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Heat shock proteins protect against stress-related phosphorylation of tau in neuronal PC12 cells that have acquired thermotolerance.
J. Neurosci. 14(9) , 5687-93, (1994) A68, or PHF-tau, is an abnormally phosphorylated form of the microtubule-associated protein tau, which is a primary protein constituent of paired helical filaments (PHFs) and, ultimately, of Alzheimer's disease-associated neurofibrillary tangles (NFTs). Previ... |
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Engineering of the yeast antioxidant enzyme Mpr1 for enhanced activity and stability.
Biotechnol. Bioeng. 103(2) , 341-52, (2009) The budding yeast Saccharomyces cerevisiae Sigma1278b has the MPR1 gene, which confers resistance to the proline analogue azetidine-2-carboxylate (AZC). This gene encodes an N-acetyltransferase Mpr1 that detoxifies AZC, and the homologous genes have been foun... |