Hymeglusin
Hymeglusin结构式
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常用名 | Hymeglusin | 英文名 | hymeglusin |
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| CAS号 | 29066-42-0 | 分子量 | 324.412 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 516.6±15.0 °C at 760 mmHg | |
| 分子式 | C18H28O5 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 181.3±13.9 °C |
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Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition.
Biochemistry 39(1) , 237-47, (2000) We have previously identified a CHO cell line (UT2 cells) that expresses only one 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase protein which is localized exclusively in peroxisomes [Engfelt, H.W., Shackelford, J.E., Aboushadi, N., Jessani, N., Ma... |
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Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Biochim. Biophys. Acta 1636(1) , 22-8, (2004) We studied the molecular mechanism through which the fungal beta-lactone, hymeglusin, potently and specifically inhibits 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase. [(14)C]Hymeglusin covalently bound to purified rat liver and to recombinant hamster cyt... |
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Biosynthesis of antibiotic 1233A (F-244) and preparation of [14C]1233A.
J. Antibiot. 45(4) , 563-7, (1992) The biosynthesis of antibiotic 1233A (F-244) was studied by feeding 13C-labeled precursors to the producing organism, Scopulariopsis sp. F-244. 13C NMR spectroscopy established that 1233A is derived from 4 methionines and 7 acetates. Seven acetates are conden... |
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Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones.
Biochem. Biophys. Res. Commun. 169(2) , 610-6, (1990) 3-Hydroxy-3-methylglutaryl CoA synthase was shown to be inhibited in a time-dependent, irreversible manner by compounds containing the substituted beta-lactone functionality found in the natural product 1233A. The rate of inactivation (kinact) was found to ap... |
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Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Arch. Biochem. Biophys. 302(1) , 265-71, (1993) Using insect (Drosophila) and rodent mammalian cell cultures we demonstrate that acute mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A was initiated in the absence of protein synthesis. In addition, insect and mammalian cells depleted... |
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Inhibition of hepatic cholesterol biosynthesis by a 3-hydroxy-3-methylglutaryl coenzyme A synthase inhibitor, 1233A, in mice.
Life Sci. 52(19) , 1595-600, (1993) We have studied the in vivo inhibition of hepatic sterol biosynthesis by 1233A, a specific inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase. Administration of the compound orally to mice resulted in a dose-dependent inhibition ... |
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The reversal of the inhibition on lipids synthesis by L-659,699 in arterial smooth muscle cells cultures.
Mol. Cell Biochem. 221(1-2) , 25-31, (2001) The beta-lactone isolated from Fusarium sp. termed L-659,699 is a potent specific inhibitor of the enzyme 3-hydroxi-3-methylglutaril coenzyme A (HMG-CoA) synthase. In cultures of smooth muscle cells (SMC) isolated from aortic-arch of control (C-SMC) and 5% of... |
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Specific binding of beta-lactone 1233A to 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
J. Antibiot. 46(5) , 872-4, (1993)
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Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase.
J. Antibiot. 40(9) , 1356-7, (1987)
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Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.
J. Org. Chem. 67(5) , 1536-47, (2002) Hepatitis A virus (HAV) 3C enzyme is a cysteine proteinase essential for viral replication and infectivity and represents a target for the development of antiviral drugs. A number of serine and threonine beta-lactones were synthesized and tested against HAV 3... |