丙亚胺
丙亚胺结构式
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常用名 | 丙亚胺 | 英文名 | Razoxane |
|---|---|---|---|---|
| CAS号 | 21416-67-1 | 分子量 | 268.26900 | |
| 密度 | 1.333g/cm3 | 沸点 | 531.5ºC at 760mmHg | |
| 分子式 | C11H16N4O4 | 熔点 | 193ºC | |
| MSDS | 美版 | 闪点 | 275.3ºC |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes.
J. Clin. Oncol. 30(10) , 1042-9, (2012) Doxorubicin causes cardiac injury and cardiomyopathy in children with acute lymphoblastic leukemia (ALL). Measuring biomarkers during therapy might help individualize treatment by immediately identifying cardiac injury and cardiomyopathy.Children with high-ri... |
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Savene® (dexrazoxane) use in clinical practice.
Support Care Cancer 20(5) , 1109-12, (2012) Anthracycline extravasation (ACEV) is a rare but potentially devastating event which can result in severe injuries including ulceration and necrosis, slow-healing lesions, serious joint damage and permanent disfigurement. It can delay further scheduled chemot... |
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Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training.
Am. J. Physiol. Heart Circ. Physiol. 302(10) , H2048-57, (2012) The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of childhood cancer. Specifically, doxorubicin (DOX) may be pa... |
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The case of the vexing vesicant.
ONS Connect 27(10) , 19, (2012)
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Cardiotoxicity in childhood cancer survivors: strategies for prevention and management.
Future Cardiol. 8(4) , 647-70, (2012) Advances in cancer treatment have greatly improved survival rates of children with cancer. However, these same chemotherapeutic or radiologic treatments may result in long-term health consequences. Anthracyclines, chemotherapeutic drugs commonly used to treat... |
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[Cardiotoxicity of conservative treatment of solid tumors].
Lik. Sprava (3-4) , 51-9, (2011) With an increasing number of long-term breast cancer survivors, the number of patients experiencing anthracycline-induced cardiotoxicity increas too. Anthracycline--and nonanthracycline-induced cardiac toxicity--clinically significant and frequent adverse eve... |
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Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.
Antioxid. Redox Signal. 18(8) , 899-929, (2013) Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of cardiotoxicity. The most feared are the chronic forms of cardiotoxicity, characterized by irreve... |
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Response-dependent and reduced treatment in lower risk Hodgkin lymphoma in children and adolescents, results of P9426: a report from the Children's Oncology Group.
Pediatr. Blood Cancer 59(7) , 1259-65, (2012) Hodgkin lymphoma is highly curable but associated with significant late effects. Reduction of total treatment would be anticipated to reduce late effects. This aim of this study was to demonstrate that a reduction in treatment was possible without compromisin... |