HA 1004 盐酸盐
HA 1004 盐酸盐结构式
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常用名 | HA 1004 盐酸盐 | 英文名 | 2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride |
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| CAS号 | 92564-34-6 | 分子量 | 329.80600 | |
| 密度 | N/A | 沸点 | 575.2ºC at 760 mmHg | |
| 分子式 | C12H16ClN5O2S | 熔点 | 235-236ºC | |
| MSDS | 美版 | 闪点 | 301.7ºC |
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Human erythropoietin receptor increases GATA-2 and Bcl-xL by a protein kinase C-dependent pathway in human erythropoietin-dependent cell line AS-E2.
Cell Growth Differ. 8 , 1317-1328, (1997) Erythropoietin (Epo) is a cytokine known to stimulate proliferation and differentiation of erythroid cells. However, recent gene disruption experiments demonstrated that Epo receptor signaling is not an obligatory step in erythroid differentiation. Here, we d... |
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cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression.
J. Biol. Chem. 272 , 3238-3245, (1997) We investigated the inhibitory effects of intracellular cyclic adenosine monophosphate (cAMP) levels in regulating class 3 aldehyde dehydrogenase (aldh3) gene expression using cultures of primary rat hepatocytes and transient transfection experiments with Hep... |
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Regulation of Schwann cell proliferation in cultured segments of the adult rat sciatic nerve.
J. Neurosci. Res. 52 , 530-537, (1998) Schwann cell proliferation was studied in cultured segments of the rat sciatic nerve by measurement of [3H] thymidine incorporation or through bromodeoxyuridine-(BrdU)-labelling and immunocytochemistry. The aim was to delineate mechanisms involved in the inju... |
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Differential effects of isoquinolinesulfonamide protein kinase inhibitors on CA1 responses in hippocampal slices.
Neuroscience 44 , 361-370, (1991) The effects of the isoquinolinesulfonamide protein kinase inhibitors 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004) on CA1 responses in hippocampal slices of the rat were examined to clarify th... |
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Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells.
Cell. Signal. 9 , 159-167, (1997) The effects of increases in intracellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) on bradykinin (BK)-induced generation of inositol phosphates (IPs) and Ca2+ mobilization were investigated in canine cultured tracheal smooth muscle cells (TSMCs). Pre... |
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HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.
J. Cardiovasc. Pharmacol. 23 , 806-813, (1994) HA1004, an isoquinolinesulfonamide and a cyclic nucleotide-dependent protein kinase inhibitor, is an intracellular calcium antagonist that produces vascular smooth muscle (VSM) relaxation in vitro. We studied the hemodynamic effects of intravenous (i.v.) infu... |
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GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors.
Neurosci. Lett. 238 , 115-118, (1997) The effects of various inhibitors on the glial cell line-derived neurotrophic factor (GDNF)-induced neurite formation in TGW human neuroblastoma cells were investigated. Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8... |