阿奇霉素二水合物
阿奇霉素二水合物结构式
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常用名 | 阿奇霉素二水合物 | 英文名 | Azithromycin Dihydrate |
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| CAS号 | 117772-70-0 | 分子量 | 785.015 | |
| 密度 | 1.18g/cm3 | 沸点 | 822.1ºC at 760mmHg | |
| 分子式 | C38H76N2O14 | 熔点 | 113-115ºC | |
| MSDS | 中文版 美版 | 闪点 | 451ºC |
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Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.
J. Chromatogr. A. 1418 , 140-9, (2015) The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directiv... |
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Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.
Biochim. Biophys. Acta 1840(9) , 2851-61, (2014) Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis was identified as a new member of the recently discovered Din... |
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A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.
Eur. J. Drug Metab. Pharmacokinet. 39(4) , 263-76, (2014) The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (PK) profile for selected derivatives in rodents in compariso... |
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Resistance behaviour of inducible clindamycin-resistant staphylococci from clinical samples and aquatic environments.
J. Med. Microbiol. 63(Pt 11) , 1446-53, (2014) In this study, the species diversity of staphylococci with inducible resistance to macrolides, lincosamides and streptogramin B (MLSB) isolated from clinical samples, sewage and river water was investigated. Inducible clindamycin resistance was tested using a... |
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In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.
Antimicrob. Agents Chemother. 59(1) , 467-74, (2014) AZD0914 is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and... |
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First record of isolation and characterization of methicillin resistant Staphylococcus lugdunensis from clinical samples in Iraq.
Biomed Res. Int. 2014 , 736259, (2014) This study was conducted to determine the frequency of Staphylococcus lugdunensis in different clinical samples. Out of 690 clinical samples, a total of 178 coagulase negative staphylococci (CoNS) isolates were recovered. CoNS were identified as 10 different ... |
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Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen.
Microbes Infect. 16(9) , 746-54, (2014) Estrella lausannensis is a new Chlamydia-related bacterium, belonging to the Criblamydiaceae family. As suggested by its species name, this bacterium harbors a peculiar star shape. E. lausannensis is able to infect a wide range of amoebal, fish and mammalian ... |
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Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.
Sci. Rep. 4 , 7438, (2014) Advanced macrolides, such as azithromycin (AZM) or clarithromycin (CLM), are antibiotics with immunomodulatory properties. Here we have sought to evaluate their in vitro influence on the activation of CD4(+) T-cells. Isolated CD4(+) T-cells were stimulated wi... |
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Prevalence of Trichomonas vaginalis, Mycoplasma genitalium and Ureaplasma urealyticum in men with urethritis attending an urban sexual health clinic.
Int. J. STD AIDS 26(6) , 388-92, (2015) We conducted a study to determine the prevalence of Trichomonas vaginalis (TV), Mycoplasma genitalium (MG) and Ureaplasma urealyticum (UU) in men with urethritis, attending an urban sexual health clinic, in order to inform screening and treatment policies. Me... |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |