鞘氨醇激酶抑制剂
鞘氨醇激酶抑制剂结构式
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常用名 | 鞘氨醇激酶抑制剂 | 英文名 | SKI II |
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| CAS号 | 312636-16-1 | 分子量 | 302.779 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 507.1±60.0 °C at 760 mmHg | |
| 分子式 | C15H11ClN2OS | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 260.5±32.9 °C |
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Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes.
PLoS ONE 10(4) , e0119005, (2015) Conjugated linoleic acid (CLA) reduces adiposity in human and mouse adipocytes. This outcome is achieved through a variety of biological responses including increased energy expenditure and fatty acid oxidation, increased inflammation, repression of fatty aci... |
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Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.
Nat. Commun. 6 , 6416, (2015) Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-sel... |
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Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells.
Arch. Pharm. Res. 37(9) , 1183-92, (2014) Ginsenoside compound K (CK) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes. This study examined the anti-angio... |
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Reversion of multidrug resistance by SKI-II in SGC7901/DDP cells and exploration of underlying mechanisms.
Asian Pac. J. Cancer Prev. 13(2) , 625-31, (2012) In order to investigate whether SKI-II could reverse drug resistance and its possible mechanisms, we treated SGC7901/DDP cells with SKI-II or SKI-II in combination with DDP. Then cell growth, apoptosis, micro- morphological changes, and expression of SphK1, P... |
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Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1.
Sci. Rep. 6 , 22141, (2016) RNA-binding protein HuR mediates transforming growth factor (TGF)-β1-induced profibrogenic actions. Up-regulation of Sphingosine kinase 1 (SphK1) is involved in TGF-β1-induced activation of hepatic stellate cells (HSCs) in liver fibrogenesis. However, the mol... |