甲磺酸西地那非
甲磺酸西地那非结构式
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常用名 | 甲磺酸西地那非 | 英文名 | WIN 55212-2 mesylate |
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| CAS号 | 131543-23-2 | 分子量 | 522.613 | |
| 密度 | N/A | 沸点 | 627.7ºC at 760 mmHg | |
| 分子式 | C28H30N2O6S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 333.4ºC |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Activation of the endocannabinoid system by organophosphorus nerve agents.
Nat. Chem. Biol. 4 , 373-8, (2008) Delta(9)-tetrahydrocannabinol (THC), the psychoactive ingredient of marijuana, has useful medicinal properties but also undesirable side effects. The brain receptor for THC, CB(1), is also activated by the endogenous cannabinoids anandamide and 2-arachidonylg... |
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Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression system.
Mol. Pharmacol. 49 , 707-714, (1996) Modulation of neuronal ion channels by the cloned rat brain CB1 cannabinoid receptor was investigated with the use of a heterologous neuronal expression system. Transient expression of the rat brain CB1 cannabinoid receptor was accomplished through microinjec... |
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The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain.
Neurosci. Lett. 221 , 157-160, (1997) The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, allev... |
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(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.
Eur. J. Pharmacol. 264 , 371-377, (1994) The effects of the novel high affinity cannabinoid receptor agonist (+)-WIN 55,212-2 ((R)-4,5-dihydro-2-methyl-4(4-morphoinylmethyl)-1-(1-naphthalen ylcarbonyl)-6H-pyrrolo[3,2,1-ij]quinolin-6-one) on severity of dystonia were investigated in mutant Syrian ham... |