NS-398(COX-2抑制剂)
NS-398(COX-2抑制剂)结构式
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常用名 | NS-398(COX-2抑制剂) | 英文名 | NS-398 |
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| CAS号 | 123653-11-2 | 分子量 | 314.357 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 490.6±55.0 °C at 760 mmHg | |
| 分子式 | C13H18N2O5S | 熔点 | 139 °C | |
| MSDS | 中文版 美版 | 闪点 | 250.5±31.5 °C |
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Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.
Invest. Ophthalmol. Vis. Sci. 55(12) , 8111-22, (2014) The purpose is to investigate the mechanism of subconjunctival fibrosis caused by benzalkonium chloride (BAC), which is the most common preservative in ophthalmic preparations.The left eyes of male Sprague-Dawley rats were topically treated with 0.01% BAC or ... |
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Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells.
Mol. Neurobiol. 51 , 1089-102, (2015) We studied the possible role of phospholipase D1 (PLD1) in the neuronal differentiation, including neurite formation of neural stem cells. PLD1 protein and PLD activity increased during neuronal differentiation. Bcl-2 also increased. Downregulation of PLD1 by... |
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Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms.
Clin. Sci. 129(1) , 39-48, (2015) The mechanisms whereby testosterone increases cardiovascular risk are not clarified. However, oxidative stress and inflammation seem to be determinants. Herein, we sought to determine whether exogenous testosterone, at physiological levels, induces leucocyte ... |
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Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 308(5) , G434-41, (2015) Abdominal pain and distention are major complaints in irritable bowel syndrome. Abdominal distention is mainly attributed to intraluminal retention of gas or solid contents, which may cause mechanical stress to the gut wall. Visceral hypersensitivity (VHS) ma... |
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Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy 10(7) , 1301-15, (2014) Mesenchymal stem cell (MSC)-based therapy is a promising approach to treat various inflammatory disorders including multiple sclerosis. However, the fate of MSCs in the inflammatory microenvironment is largely unknown. Experimental autoimmune encephalomyeliti... |
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The co-localization of HBx and COXIII upregulates COX-2 promoting HepG2 cell growth.
Int. J. Oncol. 45(3) , 1143-50, (2014) HBx is a multifunctional regulator that interacts with host factors to contribute to the development of hepatocellular carcinoma. In this study, to explore the co-localization of HBx and COXIII in HepG2 cells and to investigate the molecular mechanism of HBx ... |
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Molecules involve in the self-protection of neurons against glucose-oxygen-serum deprivation (GOSD)-induced cell damage.
Brain Res. Bull. 79 , 169-76, (2009) Molecules involved in self-protection of neurons against glucose/oxygen/serum deprivation (GOSD) were investigated. Trypan blue dye exclusion assay, Western blotting, ELISA, cytokine antibody array and chemical blocking assay were applied in the study. Result... |
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IL-6 production stimulated by CD14(+) monocytes-paracrined IL-1β does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells.
Cell Physiol. Biochem. 29(3-4) , 551-60, (2012) Human umbilical cord mesenchymal stem cells (hUC-MSCs) possess immunosuppressive activities but the mechanisms of such activities are not fully understood. Here, we investigated the role of IL-6, one of the characteristic factors of MSCs, in the immunoregulat... |
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Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice.
Brain Res. 1471 , 129-37, (2012) It is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)α) can reduce severity of stroke injury. This is supported by the finding that cPLA(2)α-deficient mice are partially protected from transient, focal cerebral ischemia. The object o... |
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Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells.
Tumour Biol. 34(3) , 1517-22, (2013) Cyclooxygenase-2 (COX-2) is a key limited enzyme of prostaglandin (PG) synthesis and has been demonstrated to be overexpressed in cancer. N-[2-(cyclohexyloxy)-4-nitropheny]-methane sulfonamide (NS-398) is a special inhibitor of COX-2 and may suppress PGE2 rel... |