L-α-羟基戊二酸二钠盐
L-α-羟基戊二酸二钠盐结构式
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常用名 | L-α-羟基戊二酸二钠盐 | 英文名 | L-2-Hydroxyglutaric acid disodium |
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| CAS号 | 63512-50-5 | 分子量 | 192.078 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C5H6Na2O5 | 熔点 | >300ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.
Anal. Biochem. 459 , 1-11, (2014) Hypoxia-inducible factor-1 alpha (HIF-1α) is an important marker of hypoxia in human tumors and has been implicated in tumor progression. Drugs targeting HIF-1α are being developed, but the ability to measure drug-induced changes in HIF-1α is limited by the l... |
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Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.
Proc. Natl. Acad. Sci. U. S. A. 110(42) , 17017-22, (2013) The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical significance of serum 2-HG levels in hematologic malignancies, ... |
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Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.
J. Clin. Oncol. 32(4) , 297-305, (2014) Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of IDH1/2 mutations at diagnosis and provide a marker of minimal... |
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Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.
Am. J. Hum. Genet. 92(4) , 627-31, (2013) The Krebs cycle is of fundamental importance for the generation of the energetic and molecular needs of both prokaryotic and eukaryotic cells. Both enantiomers of metabolite 2-hydroxyglutarate are directly linked to this pivotal biochemical pathway and are fo... |
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Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Elife 4 , e07420, (2015) The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, whic... |
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Formation of alpha-hydroxyglutaric acid by Aspergillus glaucus.
J. Bacteriol. 94(5) , 1560-4, (1967) Aspergillus glaucus, cultured on sodium propionate-mineral salts medium, incorporates (14)C-glyoxylate into labeled alpha-hydroxyglutaric acid within 30 sec. Mycelial extracts retain this biosynthetic capacity, which is destroyed by heating. Propionyl-2-(14)C... |
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Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.
Anal. Biochem. 20(2) , 335-8, (1967)
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The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.
Can. J. Biochem. 47(12) , 1103-7, (1969)
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Nature 483 , 484-488, (2012) The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating SDH and FH mutations cause the... |