3-吲哚丙酸(IPA)
3-吲哚丙酸(IPA)结构式
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常用名 | 3-吲哚丙酸(IPA) | 英文名 | 3-Indolepropionic acid |
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| CAS号 | 830-96-6 | 分子量 | 189.210 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 417.6±20.0 °C at 760 mmHg | |
| 分子式 | C11H11NO2 | 熔点 | 134-135 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 206.4±21.8 °C |
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Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency.
Sci. Rep. 5 , 11864, (2015) Serotonin is an important neurotransmitter that broadly participates in various biological processes. While serotonin deficiency has been associated with multiple pathological conditions such as depression, schizophrenia, Alzheimer's disease and Parkinson's d... |
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QSAR study on permeability of hydrophobic compounds with artificial membranes.
Bioorg. Med. Chem. 15 , 3756-67, (2007) We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of structurally diverse compounds with simple physicochemical... |
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Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.
J. Med. Chem. 52 , 2786-93, (2009) Human kynurenine aminotransferase I (hKAT I) catalyzes the formation of kynurenic acid, a neuroactive compound. Here, we report three high-resolution crystal structures (1.50-1.55 A) of hKAT I that are in complex with glycerol and each of two inhibitors of hK... |
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A novel strategy for the rapid preparation and isolation of intact immune complexes from peptide mixtures.
J. Mol. Recognit. 27(9) , 566-74, (2014) The development and application of a miniaturized affinity system for the preparation and release of intact immune complexes are demonstrated. Antibodies were reversibly affinity-adsorbed on pipette tips containing protein G´ and protein A, respectively. Anti... |
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Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.
J. Hazard. Mater. 295 , 9-16, (2015) In the present study, the enantioselective metabolism, cytotoxicity of hexaconazole and its influence on tryptophan metabolism in rat hepatocytes in vitro were investigated. Following the exposure of primary rat hepatocytes to rac-hexaconazole, the concentrat... |
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Enantioselective Metabolism and Interference on Tryptophan Metabolism of Myclobutanil in Rat Hepatocytes.
Chirality 27 , 643-9, (2015) Myclobutanil, (RS)-2-(4-chlorophenyl)-2-(1H-1, 2, 4-triazol-1-ylmethyl) hexanenitrile is a widely used triazole fungicide. In this study, enantioselective metabolism and cytotoxicity were investigated in rat hepatocytes by chiral HPLC-MS/MS and the methyl tet... |
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The control of tomato fruit elongation orchestrated by sun, ovate and fs8.1 in a wild relative of tomato.
Plant Sci. 238 , 95-104, (2015) Within the cultivated tomato germplasm, sun, ovate and fs8.1 are the three predominant QTLs controlling fruit elongation. Although SUN and OVATE have been cloned, their role in plant growth and development are not well understood. To compare and contrast the ... |
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Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.
J. Med. Chem. 52 , 6931-5, (2009) We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Th... |
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Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.
PLoS Pathog. 11 , e1005188, (2015) The ability of phagocytes to clear pathogens is an essential attribute of the innate immune response. The role of signaling lipid molecules such as phosphoinositides is well established, but the role of membrane sphingolipids in phagocytosis is largely unknow... |
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Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries.
Bioorg. Med. Chem. Lett. 21 , 1320, (2011) The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimet... |