N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine
![N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine结构式](https://image.chemsrc.com/caspic/435/86701-10-2.png)
N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine结构式
|
常用名 | N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine | 英文名 | N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine |
|---|---|---|---|---|
| CAS号 | 86701-10-2 | 分子量 | 575.74000 | |
| 密度 | 1.153 g/cm3 | 沸点 | N/A | |
| 分子式 | C30H49N5O6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
|
A small molecule inhibitor of Bcl-2, HA14-1, also inhibits ceramide glucosyltransferase.
Biochem. Biophys. Res. Commun. 433(2) , 170-4, (2013) HA14-1 is a Bcl-2 inhibitor that is widely used for studies of apoptosis. In the course of searching for a ceramide glucosyltransferase inhibitor that catalyzes the first glycosylation step of glycosphingolipid synthesis, we unexpectedly found that HA-14-1 al... |
|
|
A novel pathway of ceramide metabolism in Saccharomyces cerevisiae.
Biochem. J. 447(1) , 103-14, (2012) The hydrolysis of ceramides in yeast is catalysed by the alkaline ceramidases Ypc1p and Ydc1p, two highly homologous membrane proteins localized to the ER (endoplasmic reticulum). As observed with many enzymes, Ypc1p can also catalyse the reverse reaction, i.... |
|
|
Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.
Antimicrob. Agents Chemother. 56(8) , 4296-302, (2012) A novel and quantitative high-throughput screening approach was explored as a tool for the identification of novel compounds that inhibit chlamydial growth in mammalian cells. The assay is based on accumulation of a fluorescent marker by intracellular chlamyd... |
|
|
Labeling Golgi with fluorescent ceramides.
Cold Spring Harb. Protoc. 2012(8) , doi:10.1101/pdb.prot070599, (2012) The Golgi may be considered a principal organizer of macromolecular traffic in the cell because many molecules, such as secreted proteins, glycoproteins, glycolipids, and plasma membrane glycoproteins, pass through the Golgi during their maturation. The fluor... |
|
|
ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport.
Toxicol. Sci. 121(2) , 343-56, (2011) Cadmium (Cd(2+)) damages the kidney proximal tubule (PT) by ceramide-dependent apoptosis and is also a class I carcinogen. Multidrug resistance P-glycoprotein (MDR1, ABCB1) confers resistance to Cd(2+) apoptosis, and it has been hypothesized that ABCB1 can di... |
|
|
Effect of membrane perturbants on the activity and phase distribution of inositol phosphorylceramide synthase; development of a novel assay.
Biochemistry 43(26) , 8483-93, (2004) The effect of 26 different membrane-perturbing agents on the activity and phase distribution of inositol phosphorylceramide synthase (IPC synthase) activity in crude Candida albicans membranes was investigated. The nonionic detergents Triton X-100, Nonidet P-... |
|
|
Fluorescent staining of subcellular organelles: ER, Golgi complex, and mitochondria.
Curr. Protoc. Cell Biol. Chapter 4 , Unit 4.4, (2001) The ability to distinguish and identify specific subcellular compartments is essential to understanding organelle function, biogenesis, and maintenance within cells and to defining protein trafficking pathways. Fluorescent dyes and/or fluorescently labeled li... |
|
|
Lipopolysaccharide-induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma.
Brain Res. 895(1-2) , 59-65, (2001) Intravenous administration of lipopolysaccharide (LPS) (0.9 mg/kg) has been shown to induce ischemic tolerance in spontaneously hypertensive rats (SHR). TNF-alpha is believed to play a crucial role in preconditioning as its inhibition with TNF-alpha-binding p... |
|
|
Inhibition of yeast inositol phosphorylceramide synthase by aureobasidin A measured by a fluorometric assay.
FEBS Lett. 463(3) , 241-4, (1999) Inositol phosphorylceramide synthase (IPC synthase) is an essential and unique enzyme in fungal sphingolipid biosynthesis and is the target of the cyclic nonadepsipeptide antibiotic aureobasidin A. As a first step towards understanding the mechanism of aureob... |
|
|
D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains.
Biochemistry 45(14) , 4530-41, (2006) D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) is a frequently used inhibitor of glycosphingolipid biosynthesis. However, some interesting characteristics of D-PDMP cannot be explained by the inhibition of glycolipid synthesis alone. In the... |