4-氨基苯甲酰基-甘氨酰-脯氨酰-D-亮氨酰-D-丙氨酰异羟肟酸
4-氨基苯甲酰基-甘氨酰-脯氨酰-D-亮氨酰-D-丙氨酰异羟肟酸结构式
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常用名 | 4-氨基苯甲酰基-甘氨酰-脯氨酰-D-亮氨酰-D-丙氨酰异羟肟酸 | 英文名 | 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt |
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| CAS号 | 124168-73-6 | 分子量 | 490.553 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C23H34N6O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.
Int. J. Mol. Sci. 16 , 15659-69, (2015) Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal transducer and activator of transcription 3 (STAT3) signali... |
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Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids.
Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994) Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A water soluble inhibitor, p-NH2-Bz-Gly-Pro-D-Leu-D-Ala-NHOH (FN... |
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Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids.
Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991) To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38, 1007-1011, 1990). Among the series of tetrapeptidyl deriv... |
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Modeling of inhibitor-metalloenzyme interactions and selectivity using molecular mechanics grounded in quantum chemistry.
Proteins 31 , 42-60, (1998) We investigated the binding properties of the metalloprotease inhibitors hydroxamate, methanethiolate, and methylphosphoramidate to a model coordination site occurring in several Zn2+ metalloproteases, including thermolysin. This was carried out using both th... |
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Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions.
J. Endod. 22 , 668-673, (1996) To investigate the effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) in the root canal treatment of apical periodontitis, we studied the healing process of experimentally induced periapical lesions in rats by ... |
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Inhibition of corneal ulceration by tetrapeptidyl hydroxamic acid.
Jpn. J. Ophthalmol. 39 , 35-42, (1995) The inhibitory activity of a new peptidyl collagenase inhibitor, FN-439 or tetrapeptidyl hydroxamic acid (H2N-C6H4-CO-Gly-L-Pro-D-Leu-D-Ala-NHOH), was determined against vertebrate collagenases derived from human fibroblast, human polymorphonuclear leukocyte ... |
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A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.
EMBO Mol. Med. 3 , 370-84, (2011) Sepsis is a deadly disease characterized by the inability to regulate the inflammatory-coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorly understood and has hampered the development of effective thera... |