吗啉乙磺酸
吗啉乙磺酸结构式
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常用名 | 吗啉乙磺酸 | 英文名 | MES |
|---|---|---|---|---|
| CAS号 | 4432-31-9 | 分子量 | 195.237 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C6H13NO4S | 熔点 | >300 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations.
Cancer Chemother. Pharmacol. 75(2) , 431-7, (2015) 2-Methoxyestradiol (2ME) is a promising anti-cancer agent that disrupts the integrity and dynamics of the spindle network. In order to overcome the pharmacokinetic constraints of this compound, a panel of sulphamoylated estradiol analogues were in silico-desi... |
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Crystals of Na(+)/K(+)-ATPase with bound cisplatin.
Biochem. Pharmacol. 92(3) , 494-8, (2014) Cisplatin is the most widely used chemotherapeutics for cancer treatment, however, its administration is connected to inevitable adverse effects. Previous studies suggested that cisplatin is able to inhibit Na(+)/K(+)-ATPase (NKA), the enzyme responsible for ... |
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Stability of collapse lyophilized influenza vaccine formulations.
Int. J. Pharm. 483(1-2) , 131-41, (2015) A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process wh... |
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The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014) SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that modulate SIRT6 activity could be of great therapeutic impo... |
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Cardiolipin-incorporated liposomes with surface CRM197 for enhancing neuronal survival against neurotoxicity.
Int. J. Pharm. 473(1-2) , 334-44, (2014) CRM197-grafted liposomes containing cardiolipin (CL) (CRM197/CL-liposomes) were used to enhance the permeability of neuron growth factor (NGF) across the blood-brain barrier (BBB) for promoting the neuroprotective effect of NGF. CRM197/CL-liposoms were incuba... |
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SUMO1 promotes Aβ production via the modulation of autophagy.
Autophagy 11(1) , 100-12, (2015) Autophagy is one of the main mechanisms in the pathophysiology of neurodegenerative disease. The accumulation of autophagic vacuoles (AVs) in affected neurons is responsible for amyloid-β (Aβ) production. Previously, we reported that SUMO1 (small ubiquitin-li... |
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DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
J. Exp. Med. 211(13) , 2549-66, (2014) DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear defo... |
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Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.
Blood 124(18) , 2767-74, (2014) Telomerase is a ribonucleoprotein enzyme that is necessary for overcoming telomere shortening in human germ and stem cells. Mutations in telomerase or other telomere-maintenance proteins can lead to diseases characterized by depletion of hematopoietic stem ce... |
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Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.
BMC Genomics 16 , 151, (2015) Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRN... |
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Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.
MAbs 7(2) , 403-12, (2015) Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the foot-and-m... |