4-胍基丁酸
4-胍基丁酸结构式
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常用名 | 4-胍基丁酸 | 英文名 | 4-Guanidinobutanoic acid |
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| CAS号 | 463-00-3 | 分子量 | 145.16000 | |
| 密度 | 1.37g/cm3 | 沸点 | 377ºC at 760mmHg | |
| 分子式 | C5H11N3O2 | 熔点 | 280-282ºC (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 181.8ºC |
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Guanidino compounds in serum and urine of cirrhotic patients.
Metab. Clin. Exp. 44(5) , 584-8, (1995) To investigate the metabolic relationship between urea and guanidinosuccinic acid (GSA), we determined the levels of the guanidino compounds, including GSA, and urea in serum and urine of cirrhotic patients. Linear correlation studies between serum urea and G... |
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Influence of 72% injury in one kidney on several organs involved in guanidino compound metabolism: a time course study.
Pflugers Arch. 442(4) , 558-69, (2001) Arginine (Arg) produced from citrulline originates mostly from kidneys. Arg is involved in guanidino compound biosynthesis, which requires interorgan co-operation. In renal insufficiency, citrulline accumulates in the plasma in proportion to renal damage. Thu... |
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Anisoin: a useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds.
J. Pharm. Biomed. Anal. 42(1) , 11-6, (2006) The use of anisoin as pre-chromatographic reagent for LC analysis of guanidino compounds is proposed. The reagent reacts (5 min at 100 degrees C) with guanidino function and the resulting adducts can be chromatographed under reversed-phase conditions. A fluor... |
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Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice.
Metab. Clin. Exp. 50(12) , 1418-25, (2001) The long-term adverse consequences of early renal mass reduction in mice have not yet been investigated. The effects of partial surgical nephrectomy (NX) in 2-month-old mice on some biological parameters, on histopathologic and morphometric features of the ki... |
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Combinatorial approaches towards the discovery of new tryptase inhibitors.
Bioorg. Med. Chem. Lett. 15 , 1659-64, (2005) The synthesis and evaluation as tryptase inhibitors of a library of 2,5-diketopiperazine derivatives containing guanidine or amidine functional groups is reported. Among the compounds evaluated, derivatives 6{CG4-CG8} and 6{CG4-CG9} are the most active compou... |
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The GABA dose/conductance relationship on lobster muscle.
J. Physiol. (Paris) 75(6) , 645-9, (1979) A quantitative study was made of the action of GABA, some structurally-related agonists and antagonists on the dactyl opener muscle fibres of the lobster. It was concluded that the GABA dose/conductance relationship was better described by a two independent b... |
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Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).
Neurochem. Res. 39(10) , 1988-96, (2014) The γ-aminobutyric acid (GABA) transporters (GATs) are key membrane transporter proteins involved in the termination of GABAergic signaling at synapses in the mammalian brain and proposed drug targets in neurological disorders such as epilepsy. To date, four ... |
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Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.
Mol. Vis. 17 , 2221-7, (2011) Previous experiments from our laboratory showed that the oral intake of selected guanidino compounds could block the formation of crystallin-bound advanced ascorbylation products. Here we tested whether these were also active when applied as eye drops.Two mon... |
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Effects of starvation on guanidino compound metabolism in mice.
Res. Commun. Chem. Pathol. Pharmacol. 54(1) , 73-85, (1986) Arginine levels diminished markedly in the plasma during starvation, suggesting that plasma arginine level principally depends on food intake. Organ arginine levels were relatively stable except for an extraordinary increase in the pancreas at 96 h. Guanidino... |
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Metabolism of arginine in invertebrates: relation to urea cycle and to other guanidine derivatives.
Adv. Exp. Med. Biol. 153 , 407-17, (1982)
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