N-甲基-L-丙氨酸
N-甲基-L-丙氨酸结构式
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常用名 | N-甲基-L-丙氨酸 | 英文名 | H-N-Me-Ala-OH.HCl |
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| CAS号 | 3913-67-5 | 分子量 | 139.581 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 190.1±23.0 °C at 760 mmHg | |
| 分子式 | C4H10ClNO2 | 熔点 | 300 °C | |
| MSDS | 中文版 美版 | 闪点 | 68.8±22.6 °C |
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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been... |
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1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide.
Eur. J. Biochem. 240(1) , 118-24, (1996) Several ocytocin analogues were synthesised by substitution of the Pro residue with sarcosine or N-methylalanine, the glutamine residue with threonine and one of the cysteines with 2-mercaptopropionic acid. All the derivatives were investigated by NMR in dime... |
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Transport of L-alanine in cultured human fibroblasts: evidence for two kinetically distinguishable systems.
J. Cell Physiol. 109(1) , 37-43, (1981) The transport of L-alanine in human diploid fibroblasts was investigated. Transport measurements were performed on subcultures between the third and eighth passages with subconfluent cells growing on glass coverslips. Kinetic analysis of approximate initial r... |
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Monomeric sarcosine oxidase: 2. Kinetic studies with sarcosine, alternate substrates, and a substrate analogue.
Biochemistry 39 , 8825-9, (2000) Monomeric sarcosine oxidase (MSOX) is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine (N-methylglycine) to yield glycine, formaldehyde, and hydrogen peroxide. MSOX can oxidize other secondary amino acids (N-methyl-L-alanine, N-ethylglyci... |
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Analogue-resistant mutants of Azotobacter chroococcum derepressed for nitrogenase activity and early ammonia excretion having potential as inoculants for cereal crops.
Indian J. Exp. Biol. 38(4) , 373-8, (2000) Spontaneous mutants resistant to methionine sulfoximine (Msx), methyl alanine (Mal) and methyl ammonium chloride (Mac) were derived from A. chroococcum strain A103. Msx and Mal-resistant mutants expressed 1.73 to 10.98% of the fully derepressed nitrogenase ac... |
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Inhibition of sodium-dependent L-leucine uptake in rat brain synaptosomes.
Biochem. Pharmacol. 39(5) , 955-8, (1990) Synaptosomes isolated from adult rat cerebral cortices were used for studying the uptake of L-leucine by the Na(+)-dependent route. Three non-metabolizable amino acid analogues, which had been used previously to discriminate the Na(+)-dependent A-type uptake ... |
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Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7.
J. Med. Chem. 26(4) , 555-9, (1983) Eight analogues of oxytocin and arginine-vasopressin were synthesized, in which the proline residue in position 7 was replaced by either sarcosine or N-methylalanine; some of the pharmacological properties of these analogues were evaluated. In peptides contai... |
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A resonance Raman study on the structures of complexes of flavoprotein D-amino acid oxidase.
J. Biochem. 99(2) , 329-37, (1986) Resonance Raman (RR) spectra were obtained for the purple complexes of D-amino acid oxidase (DAO) with D-lysine or N-methylalanine. RR spectra of a complex of oxidized DAO with the oxidation product of D-lysine or D-proline were also measured. The isotope shi... |
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Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin.
Int. J. Pept. Protein Res. 23(1) , 78-83, (1984) Substituting sarcosine or N-methylalanine for proline in the inhibitory vasopressin analogs dPAVP and d(CH2)5AVP had the following effects: 1) milk ejection and antidiuretic activities were severely depressed, 2) pressor antagonism was maintained but weakened... |
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Conformational preferences and binding to neurophysins of oxytocin analogs with sarcosine or N-methylalanine in position 7.
Int. J. Pept. Protein Res. 25(4) , 375-81, (1985) The 600 MHz proton n.m.r. spectra of (sarcosyl7)-oxytocin and (N-methylalanyl7) oxytocin in 2H2O solution have been recorded and completely assigned. In each case the spectrum indicates the presence of two slowly interconverting conformers, which are the cis-... |