3-氨基-4-甲基戊酸
3-氨基-4-甲基戊酸结构式
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常用名 | 3-氨基-4-甲基戊酸 | 英文名 | 3-Amino-4-methylpentanoic acid |
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| CAS号 | 5699-54-7 | 分子量 | 131.173 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 232.0±23.0 °C at 760 mmHg | |
| 分子式 | C6H13NO2 | 熔点 | 206-209ºC | |
| MSDS | 中文版 美版 | 闪点 | 94.1±22.6 °C |
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Physiology and pathophysiology of organic acids in cerebrospinal fluid.
J. Inherit. Metab. Dis. 16(4) , 648-69, (1993) Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarboxylic acids from the brain is a major route for removing th... |
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Failure to detect beta-leucine in human blood or leucine 2,3-aminomutase in rat liver using capillary gas chromatography-mass spectrometry.
J. Biol. Chem. 263(12) , 5581-8, (1988) It has been reported (Poston, J. (1976) J. Biol. Chem. 251, 1859-1863; (1982) 255, 10067-10072; (1984) 259, 2059-2061) that mammalian tissues contain an adenosylcobalamin-dependent enzyme, leucine 2,3-aminomutase, which catalyzes the interconversion of beta-l... |
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Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency.
Blood 81(12) , 3404-13, (1993) Homocysteine can be methylated to form methionine by the cobalamin- (Cbl) and folate-dependent enzyme, methionine synthase; serum levels of total homocysteine are elevated in greater than 95% of patients with either Cbl or folate deficiency. Homocysteine can ... |
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Separation by high-performance liquid chromatography of (3R)- and (3S)-beta-leucine as diastereomeric derivatives.
Anal. Biochem. 151 , 88, (1985) For studies on the coenzyme B12-dependent enzyme, leucine-2,3-aminomutase, (3R)- and (3S)-beta-leucines were synthesized. The 10-camphorsulfonamide p-nitrobenzyl esters could be resolved by normal-phase HPLC. A much better separation was obtained by reversed-... |
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Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues.
Annu. Rev. Biochem. 55 , 855-78, (1986)
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beta-peptides as catalysts: poly-beta-leucine as a catalyst for the Juliá-Colonna asymmetric epoxidation of enones.
Chem. Commun. (Camb.) (22) , 2330-1, (2001) Poly-beta-leucines have been evaluated as catalysts for the Juliá-Colonna asymmetric epoxidation of enones; the beta 3-isomer was found to be an effective catalyst for the epoxidation of chalcone (70% ee) and some analogues. |
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Beta-leucine and the beta-keto pathway of leucine metabolism.
Adv. Enzymol. Relat. Areas Mol. Biol. 58 , 173-89, (1986)
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Cobalamin-dependent formation of leucine and beta-leucine by rat and human tissue. Changes in pernicious anemia.
J. Biol. Chem. 255(21) , 10067-72, (1980) Circulating levels of beta-leucine are elevated in the cobalamin-deficient state of pernicious anemia. Levels of leucine, on the other hand, are much lower. It is proposed that leucine 2,3-aminomutase, the cobalamin-dependent enzyme that catalyzes the interco... |
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The synthesis and detection of beta leucines.
Proc. West. Pharmacol. Soc. 24 , 117, (1981)
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Essential role of adenosylcobalamin in leucine synthesis from beta-leucine in the domestic chicken.
J. Nutr. 118(2) , 159-64, (1988) This study was designed to investigate a postulated relationship between vitamin B-12 and leucine metabolism in mature domestic chickens. Plasma amino acid analysis revealed the presence of beta-leucine at a concentration of 60 to 80 mumol/l. After 425 d on a... |