5-羟甲基脲嘧啶
5-羟甲基脲嘧啶结构式
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常用名 | 5-羟甲基脲嘧啶 | 英文名 | 5-Hydroxymethyluracil |
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| CAS号 | 4433-40-3 | 分子量 | 142.113 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 530.4ºC at 760mmHg | |
| 分子式 | C5H6N2O3 | 熔点 | >300 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 274.6ºC |
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Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.
Toxicol. Lett. 155(3) , 403-10, (2005) 5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to repair this lesion. Whether urinary levels of 5-HMU is a valid... |
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Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.
Nucleic Acids Res. 32(17) , 5291-302, (2004) Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-hydroxymethyluracil (hmU) and 5-formyluracil (fU) bearing an... |
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Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.
Radiat. Res. 161(4) , 442-50, (2004) HPLC analyses of condensed thymine irradiated with monochromatic synchrotron ultrasoft X rays in the energy region around nitrogen and oxygen K-shell edges were performed. Cobalt-60 gamma rays were used as a reference radiation. The radiation chemical dose re... |
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DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
DNA Repair (Amst.) 4(1) , 71-9, (2005) Bacteria and eukaryotes possess redundant activities that recognize and remove oxidatively damaged bases from DNA through base excision repair. DNA glycosylases excise damaged bases to initiate the base excision repair pathway. hOgg1 and hNTH1, homologues of ... |
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Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.
Nucleic Acids Res. Suppl. (1) , 167-8, (2001) To obtain the information for the role of replication protein A (RPA) on the detection of oxidized lesion in the single-stranded DNA, the binding preference of RPA purified from Xenopus egg lysate against the oligonucleotide containing one of three kinds of o... |
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Thermodynamics of organic molecule adsorption on sorbents modified with 5-hydroxy-6-methyluracil by inverse gas chromatography.
J. Chromatogr. A. 1356 , 230-5, (2014) The thermodynamic features of organic molecule adsorption from the gaseous phase of sorbents modified with 5-hydroxy-6-methyluracil (HMU) were studied. Molar internal energy and entropy of adsorption variation analyses showed that with every type surface, exc... |
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Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 764-765 , 58-63, (2014) The oxidatively modified DNA base 8-oxo-7,8-dihydroguanine (8-oxoGua) is nontoxic and weakly mutagenic. Here we report on new data suggesting a potential for 8-oxoGua to affect the expression of several genes via epigenetic changes resulting in chromatin rela... |
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Repair of deaminated bases in DNA.
Free Radic. Biol. Med. 33(7) , 886-93, (2002) Deamination of DNA bases can occur spontaneously, generating highly mutagenic lesions such as uracil, hypoxanthine, and xanthine. When cells are under oxidative stress that is induced either by oxidizing agents or by mitochondrial dysfunction, additional deam... |
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Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Nat. Chem. Biol. 10(7) , 574-81, (2014) Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5-carboxycytosine. It is currently unknown whether Tet-induced oxidation is limited to c... |
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A micro-extraction technique using a new digitally controlled syringe combined with UHPLC for assessment of urinary biomarkers of oxidatively damaged DNA.
PLoS ONE 8(3) , e58366, (2013) The formation of reactive oxygen species (ROS) within cells causes damage to biomolecules, including membrane lipids, DNA, proteins and sugars. An important type of oxidative damage is DNA base hydroxylation which leads to the formation of 8-oxo-7,8-dihydro-2... |