5-甲基吲哚-2-甲酸
5-甲基吲哚-2-甲酸结构式
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常用名 | 5-甲基吲哚-2-甲酸 | 英文名 | 5-Methyl-1H-indole-2-carboxylic acid |
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| CAS号 | 10241-97-1 | 分子量 | 175.184 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 421.2±25.0 °C at 760 mmHg | |
| 分子式 | C10H9NO2 | 熔点 | 236-238°C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 208.5±23.2 °C |
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The first potent and selective non-imidazole human histamine H4 receptor antagonists.
J. Med. Chem. 46 , 3957-3960, (2003) Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are t... |
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Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
Bioorg. Med. Chem. Lett. 20 , 6483, (2010) Structure-guided techniques were used to evolve a 5-pyridinyl pyrazole-3-carboxylate fragment into a series of 5-aryl-carbamoyl-3-phenyl-imidazole-4-carboxylates, examples of which inhibited the Pin1 PPIase with sub-μM IC 50 and blocked proliferation of prost... |
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