N-(4-氨基甲酰)-L-谷氨酸
N-(4-氨基甲酰)-L-谷氨酸结构式
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常用名 | N-(4-氨基甲酰)-L-谷氨酸 | 英文名 | N-(4-aminobenzoyl)-L-glutamic acid |
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| CAS号 | 4271-30-1 | 分子量 | 266.250 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 607.1±55.0 °C at 760 mmHg | |
| 分子式 | C12H14N2O5 | 熔点 | ~175 °C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 321.0±31.5 °C |
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Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.
J. Chromatogr. A. 1422 , 89-98, (2015) This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol en... |
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Photodegradation of folic acid in aqueous solution.
J. Pharm. Biomed. Anal. 19 , 269-275, (1999) A study of the photodegradation of folic acid by ultraviolet radiation in aqueous solution has been made. Folic acid is photolysed by an apparent first-order kinetics and the log k-pH profile shows a gradual decrease in rate in the pH range 2.0-10.0. The prof... |
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Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools.
J. Nutr. 128(11) , 1896-906, (1998) In a 10-wk study of folate metabolism in nonpregnant women (21-27 y, n -6 per group), subjects were fed a diet containing approximately 68 nmol/d (30 microg/d) folate from food. The remainder of the ingested folate was provided as folic acid in apple juice (a... |
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Purification and properties of a folate-catabolizing enzyme.
J. Biol. Chem. 275(45) , 35646-55, (2000) We have identified and purified to homogeneity an enzyme from rat liver that catalyzes the oxidative catabolism of 5-formyltetrahydrofolate to p-aminobenzoylglutamate and a pterin derivative. Purification of the enzyme utilized six column matrices, including ... |
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Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays.
Anal. Biochem. 398(2) , 150-60, (2010) New stable isotope dilution assays were developed for the simultaneous quantitation of the folates 5-methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid, tetrahydrofolic acid, 10-formylfolic acid, and folic acid as well as for their catabolites para-amin... |
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Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools.
J. Nutr. 131(7) , 1928-37, (2001) To investigate the effects of pregnancy on folate metabolism, we conducted an 84-d study in second-trimester (gestational wk 14-25) pregnant women (n = 6) and nonpregnant controls (n = 6) with stable-isotopic tracer methods. All subjects were fed a diet conta... |
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Folate catabolite excretion is responsive to changes in dietary folate intake in elderly women.
Am. J. Clin. Nutr. 77(4) , 919-23, (2003) The major route of folate turnover is by catabolic cleavage of the C9-N10 bond producing p-aminobenzoylglutamate (pABG) and its primary excretory form, p-acetamidobenzoylglutamate (ApABG). We hypothesize that total pABG (ApABG + pABG) excretion parallels both... |
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Urinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women.
J. Nutr. 130(12) , 2949-52, (2000) Folate turnover involves urinary excretion, fecal excretion, and catabolism that involves cleavage of the C9-N10 bond to yield pterins and para-aminobenzoylglutamate (pABG). Little is known about the relationship between the function of folate pools and their... |
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Increased folate catabolism following total body gamma-irradiation in mice.
J. Radiat. Res. 44(2) , 141-4, (2003) Concentrations of total folates and their oxidative degradate, para-aminobenzoyl glutamic acid, were determined in mouse after 2-7 Gy total body gamma-irradiation (TBI). Total liver folate levels were drastically reduced by almost 47% over a period of 120 h a... |
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Characterization of the folate salvage enzyme p-aminobenzoylglutamate hydrolase in plants.
Phytochemistry 69(1) , 29-37, (2008) Folates break down in vivo to give pterin and p-aminobenzoylglutamate (pABAGlu) fragments, the latter usually having a polyglutamyl tail. Pilot studies have shown that plants can hydrolyze pABAGlu and its polyglutamates to p-aminobenzoate, a folate biosynthes... |