柔红酮
柔红酮结构式
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常用名 | 柔红酮 | 英文名 | Daunomycinone |
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| CAS号 | 21794-55-8 | 分子量 | 398.36 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 677.4±55.0 °C at 760 mmHg | |
| 分子式 | C21H18O8 | 熔点 | 208-210°C | |
| MSDS | N/A | 闪点 | 243.4±25.0 °C |
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Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.
Free Radic. Res. 24(1) , 9-18, (1996) The production of semiquinone free radicals has been measured by electron paramagnetic resonance spectroscopy (EPR) in Chinese hamster ovary cells in which 7-hydroxy daunorubicin aglycone had been incorporated. The highly lipophilic daunorubicin aglycone was ... |
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Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius.
J. Basic Microbiol. 26(4) , 249-55, (1986) Aklanonic acid is an anthracyclinone-related pigment that was found to be an intermediate at an early stage of the biosynthesis of daunomycinone glycosides by Streptomyces griseus. We now isolated anthracycline-negative mutants of other Streptomyces species a... |
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Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.
J. Antibiot. 38(12) , 1714-8, (1985) Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect on leukemia P 388 cells. |
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Synthesis and cytotoxic activity of a new potent daunomycinone derivative.
Bioorg. Med. Chem. Lett. 12(24) , 3505-7, (2002) The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. The new compound was found to be less active in vitro than adriamycin against L1210 and the sensitive cell lines KB-3-1 and MES-SA, but retained interest... |
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Method for analysis, and distribution profile, of covalently-linked ferritin-daunorubicin conjugate in the blood of trypanosome-infected mice.
J. Pharm. Pharmacol. 44(1) , 48-51, (1992) Daunorubicin is a highly potent trypanocide in-vitro but is inactive in-vivo. When daunorubicin is conjugated to bovine serum albumin or horse spleen ferritin using Schiffs base linkages, the complex is trypanocidal in-vitro and in-vivo. We have developed nov... |
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Cytotoxic and mutagenic in vitro effect of 7-O-epoxyalkyl derivatives of daunomycinone. Part IX.
Neoplasma 33(3) , 297-305, (1986) The cytotoxic effect of (7S)- and (7R)-O-epoxyalkyl derivatives of daunomycinone on leukemia P388 cells was followed in in vitro tests and their mutagenicity was determined by means of the bacterial SOS chromotest. The biological effects of the substances wer... |
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Microbial transformation of semisynthetic derivatives of daunomycinone modified in ring A.
Folia Microbiol. (Praha) 34(5) , 459-62, (1989) Semisynthetic derivatives of daunomycinone with 7,9-isopropylacetal, 7-O-methyl, 7-O-(4-penten-2-yl), and 7-O-(2-hydroxyethyl) substituents were converted by Streptomyces peucetius var. caesius (an adriamycin-blocked mutant) into 7-deoxy-13-dihydrodaunomycino... |
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Erythroleukemia relapsing as precursor B-cell lymphoblastic leukemia.
Korean J. Lab. Med. 31(2) , 81-5, (2011) AML relapsing as ALL has rarely been reported. We describe the case of a 62-yr-old man who was diagnosed with erythroleukemia with a complex karyotype and achieved complete hematologic and cytogenetic remission after induction chemotherapy. However, 4 months ... |
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[Synthesis of the dipeptide derivatives of daunomycinone and adriamycinone].
Yao Xue Xue Bao 22(4) , 254-63, (1987)
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Fast atom bombardment mass spectrometric analysis of anthracyclines and anthracyclinones.
Biomed. Environ. Mass Spectrom. 17(1) , 37-45, (1988) A mass spectral characterization of a set of anthracyclines and anthracyclinones comprised of daunorubicin, adriamycin and their modified analogs was carried out by using negative and positive fast atom bombardment (FAB) ionization techniques. Addition of mor... |