7-酮基胆固醇
7-酮基胆固醇结构式
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常用名 | 7-酮基胆固醇 | 英文名 | 7-KETOCHOLESTEROL |
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| CAS号 | 566-28-9 | 分子量 | 400.637 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 516.7±29.0 °C at 760 mmHg | |
| 分子式 | C27H44O2 | 熔点 | 158-160ºC | |
| MSDS | 中文版 美版 | 闪点 | 218.5±16.9 °C |
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Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo.
J. Cell. Mol. Med. 16(10) , 2331-41, (2012) A number of cardioprotective effects, including the reduced oxidation of the low-density lipoprotein (LDL) particles, have been attributed to dietary soy isoflavones. Paraoxonase 1 (PON1), an enzyme mainly synthesized in the liver, may exhibit anti-atherogeni... |
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On-line liquid chromatography-gas chromatography: A novel approach for the analysis of phytosterol oxidation products in enriched foods.
J. Chromatogr. A. 1396 , 98-108, (2015) A novel methodology for the automated qualitative and quantitative determination of phytosterol oxidation products in enriched foods via on-line liquid chromatography-gas chromatography (LC-GC) was established. The approach is based on the LC pre-separation o... |
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Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.
J. Chromatogr. A. 1364 , 214-22, (2014) We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of several oxysterols and vitamin D metabolites in mouse brai... |
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Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.
Steroids 99 , 248-58, (2015) Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids. In addition to a ligand-binding domain, a majority of the ORPs carry a pleckstrin homology domai... |
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The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system.
Food Chem. Toxicol. 69 , 289-93, (2014) The intestinal epithelium is exposed to oxygenated cholesterol products present in foodstuffs. In vitro studies demonstrate the effect of oxysterols on cytokine release by intestinal cells cultured alone. However, physiologically, the response of the intestin... |
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7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.
Biochem. Biophys. Res. Commun. 457(3) , 324-7, (2015) Hypertension is a high-risk symptom in atherosclerotic patients, and vascular rigidity is one of the main factors leading to hypertension. β1-Subunit of BKCa channel (KCNMB1; MaxiKβ1) has been reported as a modulator of vascular flexibility. To determine the ... |
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Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.
Biochem. Pharmacol. 86(1) , 67-79, (2013) There is some evidence that oxidized derivatives of cholesterol, 7-ketocholesterol (7KC) and 7β-hydroxycholesterol (7βOHC), are increased in the plasma of patients with neurodegenerative diseases associated with demyelinization of the central nervous system (... |
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Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes
Biochim. Biophys. Acta 1833(12) , 3228-36, (2013) Autophagic flux is an important process during autophagy maturation in coronary arterial myocytes (CAMs). Here, we defined the role and molecular mechanism of the motor protein dynein in the regulation of autophagic flux in CAMs. In mouse CAMs, dynein protein... |
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Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.
Invest. Ophthalmol. Vis. Sci. 56(3) , 1658-64, (2015) The inflammatory process plays a major role in the pathogenesis of AMD, and recent data indicate the involvement of inflammasomes. Inflammasomes are intracellular structures that trigger inflammation by producing mature interleukin-(IL)-1β and IL-18. This stu... |
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7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144.
Free Radic. Biol. Med. 71 , 1-15, (2014) Oxysterol is associated with the induction of endothelial oxidative stress and impaired endothelial function. Mitochondria play a central role in oxidative energy metabolism and the maintenance of proper redox status. The purpose of this study was to determin... |