西他塞坦钠
西他塞坦钠结构式
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常用名 | 西他塞坦钠 | 英文名 | Sitaxentan sodium |
|---|---|---|---|---|
| CAS号 | 210421-74-2 | 分子量 | 476.88600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H14ClN2NaO6S2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.
Oncogenesis 4 , e146, (2015) RUNX1/ETO (RE), the t(8;21)-derived leukemic transcription factor associated with acute myeloid leukemia (AML) development, deregulates genes involved in differentiation, self-renewal and proliferation. In addition, these cells show differences in cellular ad... |
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Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates.
Biomed Res. Int. 2015 , 386165, (2015) B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the... |
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Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance.
Oncogenesis 3 , e122, (2014) Chronic myelogenous leukemia (CML) is maintained by a minor population of leukemic stem cells (LSCs) that exhibit innate resistance to tyrosine kinase inhibitors (TKIs) targeting BCR-ABL. Innate resistance can be induced by secreted bone marrow stromal cytoki... |
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Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis.
J. Leukoc. Biol. 96(5) , 833-41, (2014) Alterations in DNA methylation patterns in peripheral blood leukocytes precede atherosclerotic lesion development in mouse models of atherosclerosis and have been linked to cardiovascular death in patients. The aim of this study is to investigate the long-ter... |
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The role of Notch signaling in diabetic endothelial progenitor cells dysfunction.
J. Diabetes Complications 30 , 12-20, (2016) To investigate the role of Notch signaling pathway in vasculogenic dysfunction of diabetic EPCs (DM-EPCs).The study was performed in mice and diabetes was induced with Streptozotocin. The functional consequences of Notch pathway modulation were studied by ass... |
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Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer.
Cancer Res. 74(13) , 3603-16, (2014) Breast cancer stem-like cells (BCSC) have been implicated in tumor growth, metastasis, drug resistance, and relapse but druggable targets in appropriate subsets of this cell population have yet to be identified. Here we identify a fundamental role for the pro... |
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Surmounting intrinsic quantum-measurement uncertainties in Gaussian-state tomography with quadrature squeezing.
Sci. Rep. 5 , 12289, (2015) We reveal that quadrature squeezing can result in significantly better quantum-estimation performance with quantum heterodyne detection (of H. P. Yuen and J. H. Shapiro) as compared to quantum homodyne detection for Gaussian states, which touches an important... |
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Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
J. Immunol. 193(9) , 4654-62, (2014) Transcriptional mechanisms governing hematopoietic stem cell (HSC) quiescence, self-renewal, and differentiation are not fully understood. Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene locate... |
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Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL.
J. Lipid Res. 56(3) , 635-43, (2015) Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main protein, apoAI, are acceptors of excess cholesterol from macrophages; this process inhibits tissue inflam... |
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Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.
Innate Immunity 21(4) , 386-91, (2015) Neonates have increased susceptibility to infection, which leads to increased mortality. Whether or not this as a result of implicit deficits in neonatal innate immune function or recapitulation of innate immune effector cell populations following infection i... |