赖氨酸-(脱-精氨酸9)舒爱激肽
赖氨酸-(脱-精氨酸9)舒爱激肽结构式
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常用名 | 赖氨酸-(脱-精氨酸9)舒爱激肽 | 英文名 | Lys- [Des-Arg9] Bradykinin |
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| CAS号 | 71800-36-7 | 分子量 | 1032.20 | |
| 密度 | 1.45g/cm3 | 沸点 | N/A | |
| 分子式 | C50H73N13O11 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Potentiation of des-Arg9-kallidin-induced vasoconstrictor responses by metallopeptidase inhibition in isolated human umbilical artery.
J. Pharmacol. Exp. Ther. 313(3) , 1355-60, (2005) Several metallopeptidases have been reported to be involved in bradykinin (BK) B(1) receptor agonist metabolism. Our goal was to evaluate in vitro roles of metallopeptidases [e.g., neutral endopeptidase (NEP), aminopeptidase M (APM), and angiotensin-convertin... |
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Kinins and neuroinflammation: dual effect on prostaglandin synthesis.
Eur. J. Pharmacol. 546(1-3) , 197-200, (2006) The role of kinins, well known as peripheral inflammatory mediators, in the modulation of brain inflammation is unclear. The present data show that bradykinin, a bradykinin B(2) receptor agonist, enhanced both basal and lipopolysaccharide-induced prostaglandi... |
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Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.
Int. Immunopharmacol. 8(2) , 282-8, (2008) In the kallikrein-kinin and renin-angiotensin systems the main receptors, B1 and B2 (kinin receptors) and AT1 and AT2 (angiotensin receptors) respectively, are seven-transmembrane domain G-protein-coupled receptors. Considering that the B1 agonists Des-Arg9-B... |
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B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure.
Arterioscler. Thromb. Vasc. Biol. 25(4) , 772-7, (2005) Vascular expression of the B1 kinin receptor is markedly upregulated with left ventricular dysfunction and angiotensin-converting enzyme (ACE) inhibition, but its function remains unclear. Inhibitors of ACE potentiate bradykinin-mediated B2 receptor-dependent... |
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Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts.
J. Biol. Chem. 280(15) , 14378-84, (2005) Transforming growth factor (TGF)-beta and des-Arg(10)-kallidin stimulate the expression of connective tissue growth factor (CTGF), a matrix signaling molecule that is frequently overexpressed in fibrotic disorders. Because the early signal transduction events... |
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Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.
Eur. J. Pharmacol. 476(3) , 229-37, (2003) We evaluated roles of kinins in allergen-induced nasal blockage and sneezing, and development of nasal hyperresponsiveness to leukotriene D4 in a Japanese cedar pollen-induced allergic rhinitis model of guinea pigs. Sensitised guinea pigs were repeatedly chal... |
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Vasomotor and fibrinolytic responses to kinin receptor agonists in the atherosclerotic human lower limb.
Heart Vessels 27(2) , 179-85, (2012) Upregulation of vascular B(1) kinin receptor expression has been reported in human atheroma, but its role remains unclear. We examined vasomotor and fibrinolytic responses to selective B(1) and B(2) kinin receptor agonism in the human femoral circulation and ... |
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Induction of B1 bradykinin receptors in the kindled hippocampus increases extracellular glutamate levels: a microdialysis study.
Neuroscience 135(3) , 979-86, (2005) A link between temporal lobe epilepsy (the most common epileptic syndrome in adults) and neuropeptides has been established. Among neuropeptides, the possible involvement of bradykinin has recently received attention. An autoradiographic analysis has shown th... |
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Vascular B1 kinin receptors in patients with congestive heart failure.
J. Cardiovasc. Pharmacol. 52(5) , 438-44, (2008) Animal models suggest a vasomotor role for the B1 kinin receptor in cardiovascular disease states. In patients with heart failure treated with angiotensin-converting enzyme inhibition (ACEi), or combined B1/B2 receptor antagonism, but not B2 receptor antagoni... |
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Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.
Naunyn Schmiedebergs Arch. Pharmacol. 375(3) , 221-9, (2007) It has been known for many years that plasma and tissues contain a variety of enzymes capable of metabolizing kinins. The aim of the present study was to evaluate, by means of functional studies in a capacitance vessel such as the human umbilical vein (HUV), ... |