C: DTRP-DASP-PRO-DVAL-LEU
C: DTRP-DASP-PRO-DVAL-LEU结构式
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常用名 | C: DTRP-DASP-PRO-DVAL-LEU | 英文名 | BQ-123 |
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| CAS号 | 136553-81-6 | 分子量 | 610.701 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 1053.6±65.0 °C at 760 mmHg | |
| 分子式 | C31H42N6O7 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 591.0±34.3 °C |
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A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Sci. Signal. 8 , ra71, (2015) Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling components are substantially increased in abundance in posttraumatic osteoarthriti... |
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Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation.
Liver Transpl. 20(11) , 1296-305, (2014) An ischemic-type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts. We compared sequential subnormothermic ex vivo liver perfusion (SNEVLP; 33°C) with cold storage (CS) for the prevention ... |
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Gene expression profiling and endothelin in acute experimental pancreatitis.
World J. Gastroenterol. 18(32) , 4257-69, (2012) To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.Dibutyltin dichloride (DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,... |
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Losartan and Sodium Nitroprusside Effectively Protect against Renal Impairments after Ischemia and Reperfusion in Rats.
Biol. Pharm. Bull. 38 , 753-62, (2015) Ischemia and subsequent reperfusion are known to impair renal function. We examined several agents that might prevent renal impairment or enhance the recovery of renal function after ischemia/reperfusion injury in rats. Different degrees of preventive effects... |
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Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.
Exp. Cell Res. 319(12) , 1865-74, (2013) Here, we report a complex regulation of endothelin-1 (ET-1) axis driven by epigenetic reactions in 1833-bone metastatic cells, emphasizing the importance in skeletal metastasis from breast carcinoma. Inhibitors of histone deacetylases, trichostatin A (TSA), a... |
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Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(8) , R581-7, (2013) Antenatal steroid administration is associated with multiple cardiometabolic alterations, including hypertension; however, the mechanisms underlying this phenomenon are unclear. The aim of the present study was to ascertain, in vivo, the contribution of the e... |
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Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.
PLoS ONE 9(6) , e98818, (2014) The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involvement of ET-1/ET(A)R axis in chronic lymphocytic leukemia (... |
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BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.
Toxicol. Appl. Pharmacol. 282(3) , 275-84, (2015) Preterm birth (PTB), defined as any delivery occurring prior to the completion of 37 weeks' gestation, currently accounts for 11-12% of all births in the United States. Maternal genito-urinary infections account for up to 40% of all PTBS and induce a pro-infl... |
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Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
Am. J. Pathol. 184(11) , 3040-51, (2014) Retinopathy of prematurity adversely affects premature infants because of oxygen-induced damage of the immature retinal vasculature, resulting in pathological neovascularization (NV). Our pilot studies using the mouse model of oxygen-induced retinopathy (OIR)... |
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Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
J. Cereb. Blood Flow Metab. 35(3) , 402-11, (2015) Obstructive sleep apnea (OSA) is associated with cerebrovascular diseases. However, little is known regarding the effects of OSA on the cerebrovascular wall. We tested the hypothesis that OSA augments endothelin-1 (ET-1) constrictions of cerebral arteries. Re... |