2-氨基二环[2.2.1]庚烷-2-羧酸
![2-氨基二环[2.2.1]庚烷-2-羧酸结构式](https://image.chemsrc.com/caspic/031/20448-79-7.png)
2-氨基二环[2.2.1]庚烷-2-羧酸结构式
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常用名 | 2-氨基二环[2.2.1]庚烷-2-羧酸 | 英文名 | BCH |
|---|---|---|---|---|
| CAS号 | 20448-79-7 | 分子量 | 155.19400 | |
| 密度 | 1.256g/cm3 | 沸点 | 295.5ºC at 760 mmHg | |
| 分子式 | C8H13NO2 | 熔点 | >300 °C(lit.) | |
| MSDS | 美版 | 闪点 | 132.5ºC |
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Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.
Nat. Commun. 6 , 6479, (2015) Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundamental housekeeping and antioxidant pathways. Here we s... |
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Development of a cell-based screening method for compounds that inhibit or are transported by large neutral amino acid transporter 1, a key transporter at the blood-brain barrier.
Anal. Biochem. 486 , 81-5, (2015) Large neutral amino acid transporter 1 (LAT1) transports neutral amino acids with aromatic or branched side chains as well as their derivatives or prodrugs. Because the transporter is highly expressed at the blood-brain barrier and in some tumor cells, it is ... |
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Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Naunyn Schmiedebergs Arch. Pharmacol. 379(4) , 361-9, (2009) One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels (VSCC). We therefore analyzed the effects of gabapentin and pregabalin on K(+)-evoked release... |
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Targeting glutamine transport to suppress melanoma cell growth.
Int. J. Cancer 135(5) , 1060-71, (2014) Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each specific amino acid into cells, some of which are increased in cancer. These amino acids consequently a... |
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Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.
EMBO J. 34 , 2008-24, (2015) Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital ... |
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A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier.
Biochem. Biophys. Res. Commun. 376(2) , 267-70, (2008) Brain capillary endothelial cells control the uptake and efflux from the brain of many hydrophilic compounds due to highly specialized transporters often localized in a polarized way. Localization of Na(+)- and Cl(-)-dependent amino acid and carnitine transpo... |
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Glucose stimulation of protein acylation in the pancreatic β-cell.
Life Sci. 87(23-26) , 667-71, (2010) To determine whether protein acylation plays a role in the effects of glucose on the insulin secreting β-cell.The measurement of (3)H-palmitate incorporation into protein in the INS 832/13 cell that has a robust and well-characterized biphasic insulin secreto... |
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Production of recombinant human growth hormone conjugated with a transcytotic peptide in Pichia pastoris for effective oral protein delivery.
Amino Acids 43(2) , 717-24, (2012) Among the possible delivery routes, the oral administration of a protein is simple and achieves high patient compliance without pain. However, the low bioavailability of a protein drug in the intestine due to the physical barriers of the intestinal epithelia ... |
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Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1.
Arch. Pharm. Res. 30(4) , 444-52, (2007) Inhibition of LAT1 (L-type amino acid transporter 1) activity in tumor cells could be effective in the inhibition of tumor cell growth by depriving tumor cells of essential amino acids. Because of the high level of expression of LAT1 in tumor cells, LAT1 inhi... |
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A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model.
Biochem. Biophys. Res. Commun. 439(1) , 103-8, (2013) L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transporter ... |