马来酰亚胺基聚乙二醇单甲醚
马来酰亚胺基聚乙二醇单甲醚结构式
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常用名 | 马来酰亚胺基聚乙二醇单甲醚 | 英文名 | Methoxypolyethylene glycol maleimide |
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| CAS号 | 99126-64-4 | 分子量 | 199.20400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H13NO4 | 熔点 | 48-52 °C | |
| MSDS | 中文版 美版 | 闪点 | >110 °C |
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Studies of bioactivity, conformation and pharmacokinetic profiles of site-specific PEGylated thymosin alpha 1 derivatives.
Drug Metab. Lett. 1 , 232-240, (2007) Site-specific mono-PEGylations were performed in different conformational regions of Thymosin alpha 1 (T alpha 1) by introducing one cysteine residue into the chosen site and coupling with thiol-specific mPEG-MAL reagent. Results demonstrated that PEGylated s... |
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Site-directed pegylation of recombinant interleukin-2 at its glycosylation site.
Biotechnology 8 , 343-346, (1990) We have modified recombinant interleukin-2 (rIL-2) to facilitate site-directed covalent attachment of monomethoxy polyethylene glycol (PEG). The site chosen for modification and subsequent covalent attachment with PEG (PEGylation) was the single glycosylation... |
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Analysis of functionalization of methoxy-PEG as maleimide-PEG.
Anal. Biochem. 374 , 231-242, (2008) The design of the extension arm-facilitated PEGylation (EAFP) of proteins takes advantage of the high selective and quantitative aspects of the thiol-maleimide reaction. However, the efficiency of EAFP with hemoglobin varied with the batches of maleimide-PEG.... |
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The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.
Sci. Rep. 6 , 27484, (2016) Disulfide bond formation is crucial for the biogenesis and structure of many proteins that are localized in the intermembrane space of mitochondria. The importance of disulfide bond formation within mitochondrial proteins was extended beyond soluble intermemb... |