肌苷5'-单磷酸
肌苷5'-单磷酸结构式
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常用名 | 肌苷5'-单磷酸 | 英文名 | 5'-Inosinic Acid |
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| CAS号 | 131-99-7 | 分子量 | 348.206 | |
| 密度 | 2.3±0.1 g/cm3 | 沸点 | 793.7±70.0 °C at 760 mmHg | |
| 分子式 | C10H13N4O8P | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 433.8±35.7 °C |
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An evolving computational platform for biological mass spectrometry: workflows, statistics and data mining with MASSyPup64.
PeerJ 3 , e1401, (2015) In biological mass spectrometry, crude instrumental data need to be converted into meaningful theoretical models. Several data processing and data evaluation steps are required to come to the final results. These operations are often difficult to reproduce, b... |
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The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.
Curr. Med. Chem. 18 , 1909-1918, (2011) Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5'-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for imm... |
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Carnosine, anserine, creatine, and inosine 5'-monophosphate contents in breast and thigh meats from 5 lines of Korean native chicken.
Poult. Sci. 92(12) , 3275-82, (2013) The aim of this study was to examine the effect of chicken line on the contents of endogenous compounds, including carnosine, anserine, creatine, and inosine 5'-monophosphate (IMP), in breast and thigh meats from 5 lines of Korean native chicken for the devel... |
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A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi.
BMC Microbiol. 11 , 202, (2011) Many secondary metabolites produced by filamentous fungi have potent biological activities, to which the producer organism must be resistant. An example of pharmaceutical interest is mycophenolic acid (MPA), an immunosuppressant molecule produced by several P... |
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The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase.
Biochemistry 49 , 10674-10681, (2010) X-ray crystal structures of enzyme-ligand complexes are widely believed to mimic states in the catalytic cycle, but this presumption has seldom been carefully scrutinized. In the case of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase (IMPDH), 10... |
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Guanosine supplementation reduces the antiproliferative and apoptotic effects of the IMPDH inhibitor gnidilatimonoein in K562 cells.
Cell Biol. Int. 35 , 1001-1008, (2011) IMPDH (inosine 5'-monophosphate dehydrogenase) is the rate-limiting enzyme in the de novo biosynthetic pathway of guanine nucleotides, which is usually up-regulated in human leukaemia cell lines. Our previous studies have classified gnidilatimonoein, isolated... |
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Inosine 5'-monophosphate dehydrogenase activity as a biomarker in the field of transplantation. Glander P, Hambach P, et al.
Clin. Chim. Acta 68(6) , 913-22, (2011)
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Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
J. Biol. Chem. 288(52) , 36863-77, (2013) Umami taste perception in mammals is mediated by a heteromeric complex of two G-protein-coupled receptors, T1R1 and T1R3. T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to L-Glu, whereas mouse T1R... |
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Myocardial scintigraphy may predict the conversion to probable dementia with Lewy bodies.
Neurology 81(20) , 1741-5, (2013) To compare the usefulness of brain perfusion SPECT and (123)I-metaiodobenzylguanidine ((123)I-MIBG) in predicting the conversion of possible dementia with Lewy bodies (DLB) to probable DLB.We examined 94 patients with possible DLB based on the Consensus Crite... |