(S)-2-氨基-3-(2,4,5-三羟基苯基)丙酸
(S)-2-氨基-3-(2,4,5-三羟基苯基)丙酸结构式
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常用名 | (S)-2-氨基-3-(2,4,5-三羟基苯基)丙酸 | 英文名 | 6-Hydroxy-L-DOPA |
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| CAS号 | 27244-64-0 | 分子量 | 213.19 | |
| 密度 | 1.606g/cm3 | 沸点 | 515.2ºC at 760mmHg | |
| 分子式 | C9H11NO5 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 265.4ºC |
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The free radical site in pea seedling copper amine oxidase probed by resonance Raman spectroscopy and generated by photolysis of caged substrate.
FEBS Lett. 380(1-2) , 183-7, (1996) Resonance Raman spectra were obtained of the free radical site in substrate reduced anaerobic samples of pea seedling copper amine oxidase (PSAO). The spectra differ significantly from those reported previously for E. coli copper amine oxidase [Moenne-Loccoz ... |
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Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.
Synapse 61 , 606-614, (2007) Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A(2A) receptor antagonists might represent a promising nondopaminergic therapeutic tool for the treatment of PD. Those studies... |
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Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats.
Neurosignals 15(5) , 238-48, (2006) Overactivity of the glutamatergic system is suggested to be closely related to the onset and pathogenesis of Parkinson's disease. Vesicular glutamate transporters (VGLUT1, T2 and T3) are a group of glutamate transporters in neurons that are responsible for tr... |
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Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
Meth. Enzymol. 258 , 90-114, (1995)
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Dopaminergic denervation enhances susceptibility to hydroxyl radicals in rat neostriatum.
Amino Acids 19(1) , 183-99, (2000) To determine if greater amounts of hydroxyl radical (*OH) are formed by dopamine (DA) denervation and treatment with L-dihydroxyphenylalanine (L-DOPA), the neostriatum was DA denervated (99% reduction in DA content) by 6-hydroxydopamine treatment (134microg i... |
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Autoxidation of 4-methylcatechol: a model for the study of the biosynthesis of copper amine oxidases quinonoid cofactor.
Biochem. Biophys. Res. Commun. 214(2) , 559-67, (1995) The autoxidation of 4-methylcatechol under quasi-physiological conditions, leading to 2-hydroxy-5-methyl-1,4-benzoquinone, was investigated. The effects of pH and metal ions were examined. An electrophilic attack of dioxygen to the 4-methylcatechol monoanion ... |
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Excitotoxins L-beta-oxalyl-amino-alanine (L-BOAA) and 3,4,6-trihydroxyphenylalanine (6-OH-DOPA) inhibit [3H] alpha-amino-3- hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) binding in human hippocampus.
Neurosci. Lett. 169(1-2) , 219-22, (1994) Excitotoxins L-beta-oxalyl-amino-alanine (L-BOAA) and 3,4,6-trihydroxyphenylalanine (6-OH-DOPA) have been investigated with regard to their potency to inhibit [3H] alpha-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) binding in human hippocampus ... |
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Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor.
FEBS Lett. 371(3) , 276-8, (1995) Limited proteolysis of recombinant Hansenula polymorpha yeast amino oxidase produces a 48 kDa fragment which corresponds to the C-terminal two-thirds of the protein. The fragment contains both TOPA (2,4,5-trihydroxyphenylalanine) and copper, as well as the hi... |
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Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum.
Neuroreport 12(6) , 1123-6, (2001) We investigated the effect of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on L-DOPA-derived extracellular dopamine (DA) levels in the striatum of rats with nigrostriatal dopaminergic denervation using in vivo microdialysis. Treatment with flu... |
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Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry 49(34) , 7393-402, (2010) The copper amine oxidases carry out two copper-dependent processes: production of their own redox-active cofactor (2,4,5-trihydroxyphenylalanine quinone, TPQ) and the subsequent oxidative deamination of substrate amines. Because the same active site pocket mu... |