麻醉椒苦素
麻醉椒苦素结构式
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常用名 | 麻醉椒苦素 | 英文名 | Methylsticin |
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| CAS号 | 495-85-2 | 分子量 | 274.269 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 496.5±45.0 °C at 760 mmHg | |
| 分子式 | C15H14O5 | 熔点 | 139-140.5ºC | |
| MSDS | 美版 | 闪点 | 223.9±28.8 °C |
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Fatal kavalactone intoxication by suicidal intravenous injection.
Forensic Sci. Int. 249 , e7-11, (2015) Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were se... |
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Influence of genuine kavapyrone enantiomers on the GABA-A binding site.
Planta Med. 64(6) , 504-6, (1998) The influence of kavapyrones from Piper methysticum Forst. on the GABAA receptor was demonstrated using radioreceptor assays. Both the dienolide yangonin and the genuine enolide enantiomers (+)-kavain, (+)-dihydrokavain, (+)-methysticin, and (+)-dihydromethys... |
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Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
Planta Med. 67(4) , 306-11, (2001) Methanolic leaf and root extracts of the Hawaiian kava (Piper methysticum Forst.) cultivars, Mahakea, Nene, Purple Moi and PNG, were tested on binding affinities to CNS receptors including GABAA (GABA and benzodiazepine binding site), dopamine D2, opioid (mu ... |
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Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Phytomedicine 13(3) , 192-5, (2006) In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the mechanism of its hepatotoxicity, for example interactions ... |
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Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
Phytother Res. 25(3) , 417-23, (2011) While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, methysticin and yangonin on human hepatocytes (HepG2) and th... |
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Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
Phytomedicine 11(4) , 285-94, (2004) The effects of the herbal product kava (Kava kava, 'Awa, Yaqona, Piper methysticum) on human P450 isoforms were studied in vitro using both cDNA-expressed human enzymes and cryopreserved human hepatocytes. Increasing concentrations of an ethanolic extract of ... |
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Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.
J. Chromatogr. B. Biomed. Sci. Appl. 702(1-2) , 240-4, (1997) A simultaneous HPLC separation of the enantiomers of kavain, dihydrokavain, methysticin and dihydromethysticin, as well as the achiral dienolides yangonin and desmethoxyyangonin was carried out on a ChiraSpher NT column. For quantitative determinations, calib... |
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Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
J. Clin. Pharm. Ther. 32(3) , 233-9, (2007) To examine the bioavailability of kavalactones in vitro and the possible differences in their bioavailability because of variations in either chemical structure or the method of extraction used.Caco-2 cell monolayers were used to determine the potential bioav... |
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Kava does not display metabolic toxicity in a homogeneous cellular assay.
Planta Med. 70(4) , 289-92, (2004) To determine whether kava (Kava kava, 'Awa, Yaqona, Piper methysticum Forst.), the popular herbal product associated recently with possible human hepatotoxicity, is bioactivated by cytochrome P450 enzymes to cytotoxic metabolites, three kava lactones (methyst... |
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Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
Phytochem. Anal. 16(3) , 217-21, (2005) Three kava lactone constituents of Piper methysticum, namely, kawain, methysticin and desmethoxyyangonin, have been separated and identified by reversed-phase HPLC using superheated deuterium oxide as the mobile phase and on-line 1H-NMR detection. The method ... |