7β-羟基胆固醇
7β-羟基胆固醇结构式
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常用名 | 7β-羟基胆固醇 | 英文名 | 7Beta-Hydroxycholesterol |
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| CAS号 | 566-27-8 | 分子量 | 402.653 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 515.3±38.0 °C at 760 mmHg | |
| 分子式 | C27H46O2 | 熔点 | 165-167ºC | |
| MSDS | 中文版 美版 | 闪点 | 214.7±21.4 °C |
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Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers.
Br. J. Nutr. 114 , 368-75, (2015) Toxic oxysterols in a hypercholesterolaemia-relevant proportion cause suicidal death of human erythrocytes or eryptosis. This process proceeds through early production of reactive oxygen species (ROS), release of prostaglandin (PGE2) and opening of PGE2-depen... |
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Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.
Biochem. Pharmacol. 86(1) , 67-79, (2013) There is some evidence that oxidized derivatives of cholesterol, 7-ketocholesterol (7KC) and 7β-hydroxycholesterol (7βOHC), are increased in the plasma of patients with neurodegenerative diseases associated with demyelinization of the central nervous system (... |
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[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].
Ugeskr. Laeg. 175(5) , 285-6, (2013) Cerebrotendinous xanthomatosis (CTX) is a rare, but treatable lipid storage disorder caused by mutation in the CYP27A1 gene. The disorder results in deposition of cholestanol in various tissues. The classical CTX phenotype includes diarrhoea, juvenile catarac... |
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Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal.
Biochem. Pharmacol. 86(1) , 161-7, (2013) Oxysterols possess anti-proliferative properties that may be used with much effect in the treatment of cancer. We have demonstrated previously that 7 beta-hydroxycholesterol (7b-HC) provokes both metabolic stress, as witnessed by AMPK activation, and changes ... |
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Dimethyl sulfoxide prevents 7β-hydroxycholesterol-induced apoptosis by preserving lysosomes and mitochondria.
J. Cardiovasc. Pharmacol. 56(3) , 263-7, (2010) Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol... |
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7beta-hydroxycholesterol induces natural killer cell death via oxidative lysosomal destabilization.
Free Radic. Res. 43(11) , 1072-9, (2009) Peripheral natural killer (NK) cells are reduced in patients with coronary artery disease and highly susceptible to apoptosis induced by oxidized lipids including 7beta-hydroxycholesterol (7betaOH) in vitro. The present study aimed to further explore the mech... |
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11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol.
Biochimie 95(3) , 548-55, (2013) The atherogenic 7-oxysterols, 7-ketocholesterol (7-KC) and 7β-hydroxycholesterol (7βOHC), can directly impair arterial function. Inter-conversion of 7-KC and 7βOHC has recently been shown as a novel role for the glucocorticoid-metabolizing enzyme 11β-hydroxys... |
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Isolation and identification of two steroid compounds from Oviductus Ranae.
Nat. Prod. Res. 24(16) , 1518-22, (2010) In this study, cholest-5-en-3β,7β-diol and 3β-hydroxy-cholest-5-en-7-one were isolated from Oviductus Ranae by column chromatographies on Sephadex LH-20, octadecylsilyl (ODS) and pre high-performance liquid chromatography (HPLC). Their structures were elucida... |
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Profiling of oxidized lipid products of marine fish under acute oxidative stress.
Food Chem. Toxicol. 53 , 205-13, (2013) Free radical products including reactive oxygen species are potent to oxidize lipids and reliable measurements have been established mostly in human and rodent. To date, robust biomarkers were not used to assess the peroxidation in marine fish. The changes of... |
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Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials.
Free Radic. Res. 47(4) , 283-90, (2013) The purpose of this study was to evaluate the use of Framingham risk scores (FRRs) to identify high-risk individuals with biochemical evidence of increased oxidative damage, who may benefit from antioxidant therapies. A bimodal change in plasma F2-isoprostane... |