PK-11195
PK-11195结构式
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常用名 | PK-11195 | 英文名 | PK11195 |
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| CAS号 | 85532-75-8 | 分子量 | 352.857 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 511.7±45.0 °C at 760 mmHg | |
| 分子式 | C21H21ClN2O | 熔点 | 74-75 | |
| MSDS | 中文版 美版 | 闪点 | 263.3±28.7 °C |
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Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxam ide (PK 11195) on some mononuclear phagocyte functions.
Biochem. Pharmacol. 59 , 1305-1314, (2000) Peripheral benzodiazepine receptors (PBRs) are widely distributed throughout the body, but their functions are unknown. They are found on mononuclear phagocytes, and they are up-regulated in a number of neurological and other disease states. We explored the f... |
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Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the 'peripheral-type' benzodiazepine receptor ligand 3H-PK 11195.
Neurosci. Lett. 271 , 5, (1999) Alterations of 'peripheral-type' benzodiazepine receptors (PTBRs) in brain are a feature of hepatic encephalopathy (HE). Although ammonia toxicity has been implicated in the disorder, recent findings suggest an accumulation of manganese in the brains of cirrh... |
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Pharmacokinetics of the peripheral benzodiazepine receptor antagonist, PK 11195, in rats. The effect of dose and gender.
Pharmacol. Res. 41 , 461-468, (2000) In spite of the extensive use of the peripheral benzodiazepine (BZ) receptor antagonist, PK 11195 (PK), in pharmacological studies, there is a lack of information of its pharmacokinetics in the rat. In this study the pharmacokinetics of PK were determined aft... |
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Inhibitory regulation of amylase release in rat parotid acinar cells by benzodiazepine receptors.
Eur. J. Pharmacol. 359 , 243-249, (1998) This study examined the influence of benzodiazepine receptors on amylase release from rat parotid acinar cells. Diazepam (10(-8)-10(-6) M), which is a potent agonist of both central- and peripheral-type benzodiazepine receptors, dose dependently decreased amy... |