L-655708
L-655708结构式
|
常用名 | L-655708 | 英文名 | L-655,708 |
|---|---|---|---|---|
| CAS号 | 130477-52-0 | 分子量 | 341.36100 | |
| 密度 | 1.42g/cm3 | 沸点 | 584.4ºC at 760mmHg | |
| 分子式 | C18H19N3O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 307.2ºC |
|
Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics.
Mol. Pharmacol. 54 , 928-933, (1998) The gamma-aminobutyric acid (GABA)A receptor is a hetero-oligomer consisting of five subunits, the combination of which confers unique pharmacological properties to the receptor. To understand the physiological role of native GABAA receptors, it is critical t... |
|
|
Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain.
Brain Res. 822 , 265-270 Multiple subtypes of GABAA receptors are expressed in the rat central nervous system (CNS). To determine the distribution and proportion of alpha5 subunit containing receptors, quantitative autoradiographic analyses were performed with both [3H]L-655,708 and ... |
|
|
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
Neuropsychopharmacology 40 , 2499-509, (2015) Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve symptoms. The NMDA receptor antagonist ketamine exerts a... |
|
|
[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. Quirk, K., et al.
Neuropharmacology 356 , 1331-1335, (1996)
|