2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈
![2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈结构式](https://image.chemsrc.com/caspic/359/76081-98-6.png)
2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈结构式
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常用名 | 2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈 | 英文名 | SCH 28080 |
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| CAS号 | 76081-98-6 | 分子量 | 277.32 | |
| 密度 | 1.16g/cm3 | 沸点 | N/A | |
| 分子式 | C17H15N3O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K(+) cycling and to active Na(+) extrusion.
Biochim. Biophys. Acta 1830(8) , 4265-73, (2013) Orthophosphate (Pi) is a central compound in the metabolism of all organisms, including parasites. There are no reports regarding the mechanisms of Pi acquisition by Trypanosoma cruzi.(32)Pi influx was measured in T. cruzi epimastigotes. The expression of Pi ... |
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Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.
PLoS ONE 7(12) , e51451, (2012) Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers (NHEs) modulate the pHi, with NHE1 playing significant role... |
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Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 292(3) , G711-7, (2007) We have previously shown that stimulation of acid secretion in parietal cells causes rapid initial cell shrinkage, followed by Na(+)/H(+) exchange-mediated regulatory volume increase (RVI). The factors leading to the initial cell shrinkage are unknown. We the... |
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Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands.
Am. J. Physiol. Gastrointest. Liver Physiol. 291(5) , G838-43, (2006) The gastric H+,K+-ATPase of the parietal cell is responsible for acid secretion in the stomach and is the main target in the pharmacological treatment of acid-related diseases. Omeprazole and other benzimidazole drugs, although having delayed efficacy if take... |
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Specific H+/K(+)-ATPase inhibitors decreased contractile responses of isolated rat vas deferens.
Pharmacol. Res. 54(6) , 397-405, (2006) The effect of H(+)/K(+)-ATPase inhibitors on rat vas deferens contractility was investigated in vitro. Omeprazole (100-300microM), lansoprazole (100-300microM) and SCH 28080 (10-100microM) (2-methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile) dec... |
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Transport of inorganic phosphate in Leishmania infantum and compensatory regulation at low inorganic phosphate concentration.
Biochim. Biophys. Acta 1830(3) , 2683-9, (2013) Proliferation of Leishmania infantum depends on exogenous inorganic phosphate (P(i)) but little is known about energy metabolism and transport of P(i) across the plasma membrane in Leishmania sp.We investigated the kinetics of 32P(i) transport, the influence ... |
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[Structure-function relationship of gastric proton pump].
Seikagaku. 79(6) , 520-6, (2007)
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Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium.
Eur. J. Pharmacol. 519(3) , 259-66, (2005) The effects of three specific H+/K+-ATPase inhibitors (omeprazole, lansoprazole and SCH 28080 (2-methyl-8-(phenylmethoxy)-imidazo[1,2-a] pyridine-3-acetonitrile)) were investigated on the mechanical and electrophysiological properties of rat atrium, in vitro.... |
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Real time measurements of water flow in amphibian gastric glands: modulation via the extracellular Ca2+-sensing receptor.
J. Biol. Chem. 282(18) , 13477-86, (2007) The mechanisms for the formation of the osmotic gradient driving water movements in the gastric gland and its modulation via the extracellular Ca(2+)-sensing receptor (CaR) were investigated. Real time measurements of net water flux in the lumen of single gas... |
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Gastric H,K-ATPase as a drug target.
Dig. Dis. Sci. 51(5) , 823-33, (2006)
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